Results 241 to 250 of about 152,498 (307)

Phase I study of domatinostat (4SC‐202), a class I histone deacetylase inhibitor in patients with advanced hematological malignancies

European Journal of Haematology, 2019
Domatinostat (4SC‐202) is a selective class I histone deacetylase inhibitor (HDACi). This phase I study investigated safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and antitumor activity in patients with advanced hematological ...
Bastian Tresckow, C. Sayehli, W. Aulitzky, M. Goebeler, M. Schwab, Eunice Braz, Babett Krauss, R. Krauss, F. Hermann, R. Bartz, A. Engert   +10 more
semanticscholar   +1 more source

Histone Deacetylase Inhibitors

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Thomas A, Miller, David J, Witter, Sandro, Belvedere   +2 more
openaire   +2 more sources

HISTONE DEACETYLASE INHIBITORS

2004
The base sequence of DNA provides the genetic code for proteins. The regulation of expression or suppression of gene transcription is largely determined by the structure of the chromatin--referred to as epigenetic gene regulation (Agalioti et al., 2002; Jenuwein and Allis, 2001; Richards and Elgin, 2002; Spotswood and Turner, 2002; Zhang and Reinberg ...
JOEL SIMON, MARSON CHARLES, SAVY PASCAL
openaire   +6 more sources

Carbamazepine is an inhibitor of histone deacetylases

Life Sciences, 2005
Carbamazepine (CBZ) is a common antiepileptic drug (AED) that acts through multiple mechanisms including blockade and potentiation of cation channels and modulation of neurotransmitter levels. Whether it affects any component of the gene transcription machinery is unknown.
Andreas S, Beutler, SiDe, Li, Rebekka, Nicol, Martin J, Walsh   +3 more
openaire   +2 more sources

Prospects: Histone deacetylase inhibitors

Journal of Cellular Biochemistry, 2005
AbstractHistone deacetylase (HDAC), inhibitors represent a new class of targeted anti‐cancer agents. Several of these compounds are in clinical trials with significant activity against a spectrum of both hematologic and solid tumors at doses that are well tolerated by the patients.
Milos, Dokmanovic, Paul A, Marks
openaire   +2 more sources

Selective Histone Deacetylase Inhibitors

Anti-Cancer Agents in Medicinal Chemistry, 2012
Histone deacetylases (HDACs) are a family of conserved metalloproteases which play a key role in the development of cancer. They can be divided into 18 subtypes according to their structural diversity. Histone deacetylase inhibitors are considered as potential anti-cancer agents and a lot of pan-HDAC inhibitors have entered clinical trials.
Huili, Pan, Jiangying, Cao, Wenfang, Xu
openaire   +2 more sources

Phase II multicentre trial of oral quisinostat, a histone deacetylase inhibitor, in patients with previously treated stage IB–IVA mycosis fungoides/Sézary syndrome

British Journal of Dermatology, 2016
F. Child, P. Ortiz-Romero, R. Alvarez, M. Bagot, R. Stadler, M. Weichenthal, R. Alves, P. Quaglino, M. Beylot-Barry, R. Cowan, L. Geskin, A. Pérez-Ferriols, P. Hellemans, Y. Elsayed, C. Phelps, A. Forslund, M. Kamida, P. Zinzani   +17 more
semanticscholar   +1 more source

Hydrazides as Inhibitors of Histone Deacetylases

Journal of Medicinal Chemistry
In this Perspective, we have brought together available biological evidence on hydrazides as histone deacetylase inhibitors (HDACis) and as a distinct type of Zn-binding group (ZBG) to be reviewed for the first time in the literature. N-Alkyl hydrazides have transformed the field, providing innovative and practical chemical tools for selective and ...
Maria do Carmo Carreiras, José Marco-Contelles   +1 more
openaire   +3 more sources

Therapeutic Effect of Histone Deacetylase Inhibitor, Sodium Butyrate, on Allergic Rhinitis In Vivo

DNA and Cell Biology, 2016
Jie Wang, Li-ting Wen, Ye Wang, Fu-Quan Chen   +3 more
semanticscholar   +1 more source

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

Nature Biotechnology, 2007
P. Marks, R. Breslow
semanticscholar   +1 more source