Results 21 to 30 of about 152,498 (307)

Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: a case series report

Haematologica, 2009
Histone deacetylase inhibitors are a class of anti-neoplastic agents that induce growth arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo.
David Ritchie, Richard L. Piekarz, Piers Blombery, Laszlo J. Karai, Stefania Pittaluga, Elaine S. Jaffe, Mark Raffeld, John E. Janik, H. Miles Prince, Susan E. Bates   +9 more
doaj   +1 more source

Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy. [PDF]

PLoS ONE, 2014
Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations.
Michael Bordonaro, Eric Drago, Wafa Atamna, Darina L Lazarova   +3 more
doaj   +1 more source

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Science, 2012
Stress Protector During prolonged fasting, the oxidation of fatty acids leads to increased accumulation of d-β-hydroxybutyrate (βOHB) in the bloodstream. Such increased concentrations of βOHB inhibit class I histone deacetylases.
T. Shimazu, M. Hirschey, John C. Newman, Wenjuan He, Kotaro Shirakawa, N. Le Moan, Carrie A. Grueter, H. Lim, L. Saunders, Robert D. Stevens, Christopher B. Newgard, R. Farese, R. de Cabo, S. Ulrich, K. Akassoglou, E. Verdin   +15 more
semanticscholar   +1 more source

Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas

Haematologica, 2018
Histone deacetylase inhibitors are promising agents for various T-cell lymphomas, including cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and adult T-cell lymphoma/leukemia. CCR4 is an important therapeutic target molecule because mogamulizumab,
Akihiro Kitadate, Sho Ikeda, Fumito Abe, Naoto Takahashi, Norio Shimizu, Kosei Matsue, Hiroyuki Tagawa   +6 more
doaj   +1 more source

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Frontiers in Cell and Developmental Biology, 2020
Blindness arising from retinal or macular degeneration results in significant social, health and economic burden. While approved treatments exist for neovascular (‘wet’) age-related macular degeneration, new therapeutic targets/interventions are needed ...
Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Ailis Moran, Eugene T. Dillion, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy, Breandán N. Kennedy   +13 more
doaj   +1 more source

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

Scientific Reports, 2019
Butyrate and R-β-hydroxybutyrate are two related short chain fatty acids naturally found in mammals. Butyrate, produced by enteric butyric bacteria, is present at millimolar concentrations in the gastrointestinal tract and at lower levels in blood; R-β ...
S. Chriett, Arkadiusz Dąbek, Martyna Wojtala, H. Vidal, Aneta Balcerczyk, L. Pirola   +5 more
semanticscholar   +1 more source

Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment

International Journal of Nanomedicine, 2019
Background The efficacy of epigenetic drugs, such as histone deacetylase inhibitors, is often diminished by poor aqueous solubility resulting in limited bioavailability and a low therapeutic index.
E. Alp, F. Damkaci, Eylem Guven, M. Tenniswood   +3 more
semanticscholar   +1 more source

Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation

Cell Biology and Toxicology, 2016
The reversibility of non-genotoxic phenotypic changes has been explored in order to develop novel preventive and therapeutic approaches for cancer. Quisinostat (JNJ-26481585), a novel second-generation histone deacetylase inhibitor (HDACi), has efficient
L. Bao, Hua Diao, Nian Dong, Xiaoqiong Su, Bingbin Wang, Qiongya Mo, He-Guo Yu, Xiangdong Wang, Chengshui Chen   +8 more
semanticscholar   +1 more source

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma [PDF]

Frontiers in Cell and Developmental Biology, 2020
Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene expression by remodeling chromatin structure. An imbalance of histone acetylation caused by deregulated HDAC expression and activity is known to promote tumor progression in a number of tumor types, including neuroblastoma, the most common solid tumor in children ...
Monica Phimmachanh, Jeremy Z. R. Han, Yolande E. I. O’Donnell, Sharissa L. Latham, Sharissa L. Latham, David R. Croucher, David R. Croucher   +6 more
openaire   +3 more sources

Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression

BMC Urology, 2012
Background Prevention of bladder cancer recurrence is a central challenge in the management of this highly prevalent disease. The histone deacetylase inhibitor valproic acid (sodium valproate) has anti-angiogenic properties and has been shown to decrease
Byler Timothy K, Leocadio Dean, Shapiro Oleg, Bratslavsky Gennady, Stodgell Christopher J, Wood Ronald W, Messing Edward M, Reeder Jay E   +7 more
doaj   +1 more source