Results 21 to 30 of about 76,892 (257)

Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

Nature Communications, 2017
Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue ...
Yang Hai, Stephen A. Shinsky, Nicholas J. Porter, David W. Christianson   +3 more
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Advances in non-Hydroxamate based Histone Deacetylase Inhibitors as Anticancer Agents [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
The carcinogenesis process includes several epigenetic modifications that mainly target the silencing of tumor suppressor genes (TS genes) including ribonucleic acid (RNA) editing, deoxyribonucleic acid (DNA) hypermethylation and histone modification,
Nadine W. Nabiha, Maiy Y. Jaballahb, Rabah A.T. Serya, Khaled A.M. Abouzid   +3 more
doaj   +1 more source

The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities

Cells, 2023
Endometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription.
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis   +3 more
doaj   +1 more source

In silico profiling of histone deacetylase inhibitory activity of compounds isolated from Cajanus cajan

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Cancer is responsible for high morbidity and mortality globally. Because the overexpression of histone deacetylases (HDACs) is one of the molecular mechanisms associated with the development and progression of some diseases such as cancer ...
Kayode Adewole, Adebayo Ishola, Ige Olaoye   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Laboratory tumor lysis syndrome complicating LBH589 therapy in a patient with acute myeloid leukaemia

Haematologica, 2008
LBH589 is a novel cinnamic hydroxamic acid analog (HAA) pan-histone deacetylase inhibitor (HDACi) currently in early phase clinical development.
A. Kalff, J. Shortt, J. Farr, R. McLennan, A. Lui, J. Scott, A. Spencer   +6 more
doaj   +1 more source

Box–Behnken Assisted HPLC Development of Simultaneous Determination of Doxorubicin and Vorinostat Encapsulated into Polymeric Nanoparticles

Medical Sciences Forum, 2022
The objects of the present study are nanoparticles (NPs) based on a copolymer of lactic and glycolic acids (PLGA), loaded with the anticancer drug doxorubicin (DOX-NP) and histone deacetylase inhibitor vorinostat (SAHA-NP) and developed for breast cancer
Maria Sokol, Ivan Gulyaev, Mariia Mollaeva, Sergey Kuznetsov, Vladimir Zenin, Maksim Klimenko, Nikita Yabbarov, Margarita Chirkina, Elena Nikolskaya   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The Potential Role of Epigenetic Drugs in the Treatment of Anxiety Disorders

Neuropsychiatric Disease and Treatment, 2020
Jacob Peedicayil Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaCorrespondence: Jacob PeedicayilDepartment of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, IndiaTel/Fax +91-
Peedicayil J
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