Results 21 to 30 of about 208,828 (307)

Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]

, 2012
The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Grez, Manuel, Katryniok, Careen, Metzner, Julia, Pufahl, Laura, Schnur, Nicole, Sorg, Bernd Lothar, Steinhilber, Dieter   +6 more
core   +1 more source

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

Scientific Reports, 2019
Butyrate and R-β-hydroxybutyrate are two related short chain fatty acids naturally found in mammals. Butyrate, produced by enteric butyric bacteria, is present at millimolar concentrations in the gastrointestinal tract and at lower levels in blood; R-β ...
S. Chriett, Arkadiusz Dąbek, Martyna Wojtala, H. Vidal, A. Balcerczyk, L. Pirola   +5 more
semanticscholar   +1 more source

Histone-Deacetylase Inhibitors for the Treatment of Cancer [PDF]

Cell Cycle, 2004
Histone deacetylase inhibitors (HDACi) are a promising new class of chemotherapeutic drug currently in early phase clinical trials. A large number of structurally diverse HDACi have been purified or synthesised that mostly inhibit the activity of all eleven class I and II HDACs.
Lindemann, Ralph K., Gabrielli, Brian G., Johnstone, Ricky W.   +2 more
openaire   +4 more sources

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Frontiers in Cell and Developmental Biology, 2020
Blindness arising from retinal or macular degeneration results in significant social, health and economic burden. While approved treatments exist for neovascular (‘wet’) age-related macular degeneration, new therapeutic targets/interventions are needed ...
Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Ailis Moran, Eugene T. Dillion, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy, Breandán N. Kennedy   +13 more
doaj   +1 more source

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation [PDF]

, 2017
Current antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus ...
Albert, Brice J, Barnes, Alexander B, Kyei, George B, Marshall, Garland R, Niu, Austin, Ramani, Rashmi, Ratner, Lee, Wender, Paul A, Williams, Robert M   +8 more
core   +2 more sources

Histone Deacetylase Inhibitors [PDF]

Journal of Thoracic Oncology, 2011
Histone modification and DNA methylation are critical events that determine gene expression. Histone deacetylases (HDAC) render several critical genes transcriptionally inactive by conferring a “hyperwound” configuration. HDAC inhibition leads to unwinding of the DNA and makes it available to the transcriptional machinery for expression of a number of ...
openaire   +2 more sources

Non-Hydroxamate Histone Deacetylase Inhibitors [PDF]

Current Medicinal Chemistry, 2005
A number of histone deacetylase (HDAC) inhibitors have been developed as anticancer agents and most of them are hydroxamic acid derivatives, typified by suberoylanilide hydroxamic acid (SAHA), Trichostatin A (TSA) and NVP-LAQ824. However, hydroxamic acids have been associated with poor pharmacokinetics and severe toxicity. In addition, although isozyme-
Takayoshi, Suzuki, Naoki, Miyata
openaire   +2 more sources

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation

Cell Biology and Toxicology, 2016
The reversibility of non-genotoxic phenotypic changes has been explored in order to develop novel preventive and therapeutic approaches for cancer. Quisinostat (JNJ-26481585), a novel second-generation histone deacetylase inhibitor (HDACi), has efficient
Lianmin Bao, Hua Diao, Nian Dong, Xiaoqiong Su, Bingbin Wang, Qiongya Mo, Heguo Yu, Xiangdong Wang, Chengshui Chen   +8 more
semanticscholar   +1 more source

Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. [PDF]

PLoS ONE, 2012
Acetylation is mediated by acetyltransferases and deacetylases, and occurs not only on histones but also on diverse proteins. Although histone acetylation in chromatin structure and transcription has been well studied, the biological roles of non-histone
Masahide Fukada, Atsuko Hanai, Atsuo Nakayama, Takayoshi Suzuki, Naoki Miyata, Ramona M Rodriguiz, William C Wetsel, Tso-Pang Yao, Yoshiharu Kawaguchi   +8 more
doaj   +1 more source