Results 31 to 40 of about 208,828 (307)

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells [PDF]

, 2018
Sirtuin 6 (SIRT6) is a member of the NAD+-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy.
Annamaria Biroccio, And, Del Bufalo, Donatella, Di Leo, Luca, Iachettini, Sara, Leonetti, Carlo, Lucidi, Alessia, Mai, Antonello, Rizzo, Angela, Rosa Ciriolo, Maria, Rotili, Dante, Salvati, Erica, Steegborn, Clemens, Trisciuoglio, Daniela, Zizza, Pasquale   +13 more
core   +2 more sources

Inhibitors of Histone Deacetylases [PDF]

Journal of Biological Chemistry, 2011
Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.
Kelly Huber, Geneviève Doyon, Joseph Plaks, Elizabeth Fyne, John W. Mellors, Nicolas Sluis-Cremer   +5 more
openaire   +1 more source

Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression

BMC Urology, 2012
Background Prevention of bladder cancer recurrence is a central challenge in the management of this highly prevalent disease. The histone deacetylase inhibitor valproic acid (sodium valproate) has anti-angiogenic properties and has been shown to decrease
Byler Timothy K, Leocadio Dean, Shapiro Oleg, Bratslavsky Gennady, Stodgell Christopher J, Wood Ronald W, Messing Edward M, Reeder Jay E   +7 more
doaj   +1 more source

Fermented Wheat Germ Protein with Histone Deacetylase Inhibitor AR42 Demonstrates Enhanced Cytotoxicity against Lymphoma Cells In Vitro and In Vivo. [PDF]

Int J Mol Sci
Meckler JF, Levis DJ, Kong Y, O'Donnell RT, Vang DP, Tuscano JM.   +5 more
europepmc   +3 more sources

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal [PDF]

, 2018
Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases.
Battistelli, Cecilia, Bordoni, Veronica, DE TURRIS, Valeria, Domenici, Alessandro, Mai, Antonello, Manzione, Andrea, Mene', Paolo, Moioli, Alessandra, Noce, Valeria, Palladino, Marco, Rossi, Lucia, Strippoli, Raffaele, Tripodi, Marco, Valente, Sergio, Zwergel, Clemens   +14 more
core   +1 more source

Histone deacetylase inhibitors

Journal of Education, Health and Sport, 2020
The human genome is contained in chromatin, which is a complex macromolecular complex. It is made of DNA, histones and non-histone proteins. The structure of chromatin and the process of its rearrangement regulate the process of transcription, and hence gene expression.
Marzena Baran, Paulina Anna Miziak, Katarzyna Bonio   +2 more
openaire   +7 more sources

Butyrate Histone Deacetylase Inhibitors

BioResearch Open Access, 2012
In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in gynecological cancer cells, inhibiting DNA synthesis and cell growth in colonic tumor cell lines, suppressing hTERT mRNA expression and telomerase activity in human ...
Steliou, Kosta, Boosalis, Michael S., Perrine, Susan P., Sangerman, José, Faller, Douglas V.   +4 more
openaire   +3 more sources

Epigenetic modulation of immunotherapy cofactors to enhance tumor response in lung cancer

Human Vaccines & Immunotherapeutics, 2021
Immunotherapy with a checkpoint inhibitor has revolutionized the treatment of advanced non-small cell lung cancer. Replacing cytotoxic chemotherapy in some settings, immunotherapy with checkpoint inhibitors enables many patients to live longer with much ...
Anuhya Kommalapati, Tawee Tanvetyanon
doaj   +1 more source

Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]

, 2017
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello, Mazzone, Roberta, Valente, Sergio, Zwergel, Clemens   +3 more
core   +1 more source

New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer

Journal of Hematology & Oncology, 2009
DNA methylation and histone acetylation are two well known epigenetic chromatin modifications. Epigenetic agents leading to DNA hypomethylation and histone hyperacetylation have been approved for treatment of hematological disorders.
Ma Yuehua, Cang Shundong, Liu Delong
doaj   +1 more source