Results 31 to 40 of about 152,498 (307)
Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. [PDF]
PLoS ONE, 2012 Acetylation is mediated by acetyltransferases and deacetylases, and occurs not only on histones but also on diverse proteins. Although histone acetylation in chromatin structure and transcription has been well studied, the biological roles of non-histone
Masahide Fukada +8 more
doaj +1 more source
New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer
Journal of Hematology & Oncology, 2009 DNA methylation and histone acetylation are two well known epigenetic chromatin modifications. Epigenetic agents leading to DNA hypomethylation and histone hyperacetylation have been approved for treatment of hematological disorders.
Ma Yuehua, Cang Shundong, Liu Delong
doaj +1 more source
Epigenetic modulation of immunotherapy cofactors to enhance tumor response in lung cancer
Human Vaccines & Immunotherapeutics, 2021 Immunotherapy with a checkpoint inhibitor has revolutionized the treatment of advanced non-small cell lung cancer. Replacing cytotoxic chemotherapy in some settings, immunotherapy with checkpoint inhibitors enables many patients to live longer with much ...
Anuhya Kommalapati, Tawee Tanvetyanon
doaj +1 more source
Aging Cell, 2015 Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major contributor to disability and frailty in the elderly. Previous studies found a protective effect of reduced histone deacetylase activity in models of neurogenic muscle ...
Michael E Walsh +7 more
semanticscholar +1 more source
International Journal of Radiation Oncology, Biology, Physics, 2015 Purpose Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor (HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in pre-clinical models. We evaluated the addition of VPA to standard radiation therapy (RT)
A. Krauze +8 more
semanticscholar +1 more source
Histone acetylation modifiers in the pathogenesis of Alzheimer’s disease
Frontiers in Cellular Neuroscience, 2015 It is becoming more evident that histone acetylation, as one of the epigenetic modifications or markers, plays a key role in the etiology of Alzheimer’s disease (AD).
Xi eLu +4 more
doaj +1 more source
Fertility & Reproduction, 2023 Background and Aims: While the histone deacetylase inhibitor Scriptaid has been reported to be effective to improve ROSI results, there are also reports that offspring born after its use are stunted.
Atsushi Tanaka +5 more
doaj +1 more source
Synergy of Histone-Deacetylase Inhibitor AR-42 with Cisplatin in Bladder Cancer
Journal of Urology, 2015 Purpose: Cisplatin based chemotherapy regimens form the basis of systemic bladder cancer treatment, although they show limited response rates and efficacy.
David R. Li +6 more
semanticscholar +1 more source
Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
Nature Communications, 2017 Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue ...
Yang Hai +3 more
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PLoS Pathogens, 2014 Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation of HIV expression in latently infected cells is being explored as one of the strategies to ...
D. Wei +21 more
semanticscholar +1 more source