Results 191 to 200 of about 138,704 (292)

New potent N-hydroxycinnamamide-based histone deacetylase inhibitors suppress proliferation and trigger apoptosis in THP-1 leukaemia cells. [PDF]

Arch Pharm (Weinheim)
Onuscakova M, Kauerova T, Fialova E, Pizova H, Garaj V, Kemka M, Frecer V, Kollar P, Bobal P.   +8 more
europepmc   +1 more source

A Voxel‐Wise T2 Distribution Framework for Lesion Severity Stratification and Treatment‐Response Assessment in Stroke: Insights Into Suberoylanilide Hydroxamic Acid‐Induced Neuroprotection

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate lesion severity distribution in ischaemic brain lesions in spontaneously hypertensive rats (SHR) subjected to 90‐min transient middle cerebral artery occlusion (tMCAO), and to determine whether epigenetically based neuroprotection modifies lesion severity profiles using a voxel‐wise T2 distribution framework.
Andrea Díaz‐Pérez, Clara Penas, Francesc Jiménez‐Altayó, Silvia Lope‐Piedrafita   +3 more
wiley   +1 more source

Acetylation and Histone Deacetylase Inhibitors in Cancer

Cellular Oncology, 2006
Madeleine S. Q. Kortenhorst, Michael A. Carducci, Shabana Shabbeer   +2 more
doaj   +1 more source

Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer. [PDF]

J Control Release
Li J, Arnold J, Sima M, Al Faruque H, Galang J, Hu-Lieskovan S, Kopeček J, Yang J.   +7 more
europepmc   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrest. [PDF]

Sci Rep
Li Z, Qiu H, Lu W, Duan N, Fan S, Zhou R, Li X, Zhang H, Liu N, Yang F.   +9 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Combination Therapy with Immune Checkpoint Inhibitors and Histone Deacetylase Inhibitors or Alkylating Agents. [PDF]

Cancer Manag Res
Joerger M, Koster KL, Janik T, de Jong FA.   +3 more
europepmc   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview. [PDF]

Pharmaceuticals (Basel)
Seane EN, Nair S, Vandevoorde C, Joubert A.   +3 more
europepmc   +1 more source