Results 131 to 140 of about 28,454 (236)

Histone demethylase KDM4B epigenetically controls NLRP3 expression to enhance inflammatory responses. [PDF]

EMBO Mol Med
Tong L, Song H, Gao Y, Qin D, Wang C, Li Q, Fu Y, Zhao C, Ying Z, Chen D, Gao C, Han C, Zhao W, Qin Y, Zhang L.   +14 more
europepmc   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5. [PDF]

Epigenetics Chromatin
Yheskel M, Castiglione MA, Secombe J.
europepmc   +1 more source

Epigenetic modifications regulate peg elongation and underground fruiting in peanut in response to environmental cues

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Epigenetic regulation plays a central role in coordinating peanut (Arachis hypogaea L.) fruit pegging, a unique developmental process in which fertilized ovaries transition from aerial growth to subterranean pod formation. This review synthesizes current evidence demonstrating that dynamic interactions among DNA methylation, histone ...
Yohannes Gelaye, Huaiyong Luo
wiley   +1 more source

Correction: Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling. [PDF]

Mol Cancer
Hu F, Li H, Liu L, Xu F, Lai S, Luo X, Hu J, Yang X.   +7 more
europepmc   +1 more source

The mirage of DNA methylation in transcriptional regulation of plants

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract “Cytosine methylation plays an important role in the regulation of gene expression in plants.” Some iteration of this statement can be found in most papers centered on plant epigenetics and has become a widely accepted textbook claim. However, our generalized understanding of how DNA methylation exerts control over transcription is now ...
Peter Civan, Iris Sammarco, Meriem Banouh   +2 more
wiley   +1 more source

Histone demethylase KDM7A negatively regulates fibrotic macrophage polarization and lung fibrosis progression. [PDF]

Commun Biol
Funagura N, Koga T, Etoh K, Hong S, Ichiyasu H, Fujijwara Y, Yasunaga KI, Usuki S, Noda A, Sagara A, Hino S, Komohara Y, Sakagami T, Inoue T, Nakao M.   +14 more
europepmc   +1 more source

A Temperature Increase Induces Atf1/Pcr1‐Dependent Rapid Depletion of Histones in Transcriptionally Activated Gene Bodies in Fission Yeast

Genes to Cells, Volume 31, Issue 2, March 2026.
In the fission yeast Schizosaccharomyces pombe, the transcription factor complex Atf1‐Pcr1 is activated by phosphorylation upon heat stress to initiate a rapid cellular response. This activated complex facilitates the significant eviction of histone H3 from the transcribed regions of specific genes termed HOT‐DOGs. RNAP II, depicted as delivery trucks,
Arata Hoshino, Takuya Kajitani, Masaya Oki, Tetsuji Kakutani, Soichi Inagaki   +4 more
wiley   +1 more source

Targeting epigenetic regulators: In-silico discovery of natural inhibitors against histone demethylase KDM4C. [PDF]

PLoS One
Kumar M, P A, Mukhopadhyay S, Chowdhury S, Phalak M, Devi U, Shukla PK.   +6 more
europepmc   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source