Results 131 to 140 of about 29,619 (246)

Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming. [PDF]

JCI Insight
Wanner N, Keller J, Liaukouskaya N, Andrieux G, Laufer SD, Rogg M, Bork T, Liang W, Braun F, Haas F, Wong MN, Puelles VG, Gies SE, Meyer C, Boerries M, Helmstädter M, Kretz O, Hild I, Metzger E, Schüle R, Bechtel-Walz W, Huber TB.   +21 more
europepmc   +1 more source

G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation

Advanced Science, Volume 13, Issue 45, 13 August 2026.
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang, Qingqing Xu, Yuxin Zhang, Fang Liu, Guangchao Sui, Dangdang Li   +5 more
wiley   +1 more source

Histone demethylase PHF2 regulates inflammatory genes in Alzheimer's disease. [PDF]

Mol Psychiatry
Yang G, Ren Y, Zhong P, Patel PJ, Chen XQ, Wan L, Lee YH, Saleem K, Feng J, Yan Z.   +9 more
europepmc   +1 more source

The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution

BioEssays, Volume 48, Issue 8, August 2026.
p53 is an adaptive processor positioned at the interface between metabolism and the tumor microenvironment. By integrating nutrient, mechanical, inflammatory, and redox cues while reciprocally remodeling metabolism, stromal and immune compartments, and cancer cell plasticity, WT and mutant p53 orchestrate cell competition, tumor evolution, metastasis ...
Sebastien M. Joruiz, Francesco Napoletano, Rebecca Bertolio, Giannino Del Sal   +3 more
wiley   +1 more source

Targeting epigenetic regulators: In-silico discovery of natural inhibitors against histone demethylase KDM4C. [PDF]

PLoS One
Kumar M, P A, Mukhopadhyay S, Chowdhury S, Phalak M, Devi U, Shukla PK.   +6 more
europepmc   +1 more source

Epigenetic Mechanisms Underlying Cognitive Dysfunction in Parkinson's Disease: Current Evidence and Future Prospects

Brain and Behavior, Volume 16, Issue 8, August 2026.
Epigenetic mechanismsincluding DNA methylation, histone modifications, and microRNA (miRNA) regulationmodulate gene expression without altering the DNA sequence and are increasingly implicated in the cognitive impairment associated with Parkinson's disease (PD). Environmental and molecular factors influence these epigenetic pathways, leading to altered
Fatemeh Hasani, Mohammad Ebrahim Kherad, Mohammad Sharifi Sarasyabi, Kimia Jazi, Ali Ashkbari, Payam Ahmadi, Hadise Heidarpour, Mahdi Masrour, Sina Khamaki, Rahem Rahmati, Andrei Surguchov   +10 more
wiley   +1 more source

Correction: Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling. [PDF]

Mol Cancer
Hu F, Li H, Liu L, Xu F, Lai S, Luo X, Hu J, Yang X.   +7 more
europepmc   +1 more source

TET2 as a Context‐Dependent Epigenetic Integrator in Clonal Hematopoiesis, Inflammation, Cancer, and Immunotherapy

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Ten‐Eleven Translocation 2 (TET2) is an Fe(II)‐ and α‐ketoglutarate‐dependent dioxygenase that initiates active DNA demethylation by oxidizing 5‐methylcytosine (5mC). Beyond this enzymatic role, TET2 links DNA methylation dynamics with chromatin regulation, cellular metabolism, immune‐cell identity, and treatment response in a context ...
XiaoJie Liu, Jiangchen Liu, Liu Feng, Dan Xu, Xianling Wei, Dekuai Tong   +5 more
wiley   +1 more source

Histone demethylase KDM7A negatively regulates fibrotic macrophage polarization and lung fibrosis progression. [PDF]

Commun Biol
Funagura N, Koga T, Etoh K, Hong S, Ichiyasu H, Fujijwara Y, Yasunaga KI, Usuki S, Noda A, Sagara A, Hino S, Komohara Y, Sakagami T, Inoue T, Nakao M.   +14 more
europepmc   +1 more source

Epigenetic Regulation of Bone Homeostasis in Osteoporosis: Mechanisms, Evidence Gaps, and Translational Prospects

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Osteoporosis arises from an imbalance among osteoblast‐mediated bone formation, osteoclast‐mediated bone resorption, and osteocyte‐directed mechanosensory control, but the molecular events that connect aging, hormonal change, inflammation, and mechanical unloading to bone loss remain incompletely resolved.
Minjuan Du, Leisheng Wang
wiley   +1 more source