Results 171 to 180 of about 29,619 (246)

Histone demethylase LSD1 regulates lipid homeostasis during <i>Cryptococcus neoformans</i> infection. [PDF]

iScience
Lohia GK, Shah A, Balaji KN.
europepmc   +1 more source

Dual‐Targeting, Hybrid Antifungal Agents Targeting Candida albicans—An Overview

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The selective, single‐targeting antifungal agents serve as the parent molecule(s) for the design of dual‐targeting, hybrid fungicidal agents and are discussed and compared, which enables the researchers to understand the logic for designing multi‐targeting new chemical entities (NCEs) that can exhibit dual‐sword attack on Candida albicans. ABSTRACT Due
Sarmistha Pal, Sriparna Pusti, Iftakhar Hussain Ansari, Sanchita Pradhan, Hritabrata Bhattacharya, Shuvradip Das   +5 more
wiley   +1 more source

Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules. [PDF]

Adv Sci (Weinh)
Liu X, Liu X, Xue M, Xiao Y, Chen Y, Qiu R, Wu D, Zhou Y, Wang J, Yuan Y, Yu L, Shi T, Li Y, Su H, Chen H, Liu Y, Huang K, Zheng L.   +17 more
europepmc   +1 more source

Comprehensive Assessment of the KDM2B‐Associated Neurodevelopmental Disorder and the 12q24.31 Microdeletion Syndrome

Clinical Genetics, Volume 110, Issue 2, Page 150-164, August 2026.
We set out to characterize genotype–phenotype correlations in the recently delineated KDM2B‐associated neurodevelopmental disorder. We observe a highly penetrant CxxC domain‐related phenotype with distinct facial features supported by GestaltMatcher. In contrast, our findings point to variable expressivity and incomplete penetrance of loss‐of‐function ...
Amber S. E. van Oirsouw, Tzung‐Chien Hsieh, Martijn Koetsier, Abdulrazak Alali, Fatimah Albuainain, Elena Bacchelli, Tahsin Stefan Barakat, Yline Capri, Sandra Chantot‐Bastaraud, Valeria Capra, Deanna Alexis Carere, Emma Clement, Nour Elkhateeb, Madeleine Franchi, Jing‐Mei Li, Nicole Matthews, Vanda McNiven, Sarju G. Mehta, Masayuki Nakamura, Chanika Phornphutkul, Nicole Revencu, Marcello Scala, Natalie Shallow, Jennifer Stefanich, Marta Viggiano, Paola Visconti, Susan Walker, Federico Zara, Mariëlle Alders, Bobby P. C. Koeleman, Renske Oegema   +30 more
wiley   +1 more source

Abacavir enhances the efficacy of doxorubicin via inhibition of histone demethylase KDM5B in breast cancer. [PDF]

Sci Rep
Jose A, Kulkarni P, Kumar NA, Usman N, Rodrigues GS, Shenoy GG, Damerla RR, Munisamy M, Bisht B, Varambally S, Paul MK, Arya N, Rao PP, Rao M.   +13 more
europepmc   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Natural variation in histone demethylase GmLDL2 confers flowering time divergence for geographical expansion in soybean. [PDF]

Nat Commun
Liu M, Fang Y, Jiang J, Chen H, Yang B, Xu X, Liu G, Ling C, Dong Z, Yang C, Wang Y.   +10 more
europepmc   +1 more source

Interferon‐Mediated Regulation of Memory B Cell Identity and Function

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Memory B cells are essential for long‐lasting immunity induced by both encountered pathogens and vaccines. Functional diversity within the memory B cell pool is established through interactions between memory B cells and the environment in which they develop and reside.
Alana Kirn, Kim L. Good‐Jacobson
wiley   +1 more source

SMAD1/5-mediated recruitment of the histone demethylase KDM1A controls cell fate programs in embryonic stem cells. [PDF]

J Biol Chem
Morikawa M, Koinuma D, Sakai H, Kanda Y, Yuki K, Okamoto K, Miyazono K.   +6 more
europepmc   +1 more source

Epigenetic Activation of the KDM6B‐DKK1 Axis Promotes Colorectal Cancer Peritoneal Metastasis Through Wnt/β‐Catenin‐Associated EMT

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT Peritoneal metastasis (PM) is a highly lethal pattern of progression in colorectal cancer (CRC), yet the specific molecular drivers and upstream regulatory mechanisms underlying this process remain incompletely understood. In the present study, public transcriptomic datasets from TCGA and GEO were integrated to identify PM‐associated genes in ...
Zhichao Zhai, Jiajia Chen, Yong Yang, Ming Li   +3 more
wiley   +1 more source