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The emerging functions of histone demethylases
Current Opinion in Genetics & Development, 2008Epigenetic information refers to heritable changes in gene function that are stable between cell divisions but which is not a result of changes in the DNA sequence. Part of the epigenetic mechanism has been ascribed to modifications of histones or DNA that affects the transcription of specific genes. In this context, post-translational modifications of
Agger, Karl +3 more
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Histone methylation is a dynamic process that contributes to the control of gene expression by influencing chromatin structure. Since their initial discovery 20 years ago, histone demethylases have been shown to play a critical role in histone methylation and thus developmental, physiological, and pathological processes.
Stephen C. Kales, Anton Simeonov
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Stephen C. Kales, Anton Simeonov
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Histone demethylases in development and disease
Trends in Cell Biology, 2010Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a
Pedersen, Marianne Terndrup +1 more
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Histone demethylases and cancer.
Advances in cancer research, 2009Epigenetic modifications are heritable chromatin alterations that contribute to the temporal and spatial interpretation of the genome. The epigenetic information is conveyed through a multitude of chemical modifications, including DNA methylation, reversible modifications of histones, and ATP-dependent nucleosomal remodeling.
Sotirios C, Kampranis +1 more
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Interfering with histone demethylases in HSCs
Blood, 2013In this issue of Blood , Cellot et al identify the histone demethylase Jarid1b as a key regulator of renewal and differentiation in hematopoietic stem cells (HSCs).[1][1] ![Figure][2] Proposed model for JARID1B activity in HSC regulation.
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Histone Demethylases in Prostate Cancer
2013Accumulating evidence has suggested that epigenetic alternations are as important as genetic mutations in cancer development. It is proposed that tumors are arisen by “malignant reprogramming” driven by a combination of both genetic and epigenetic changes.
Ling-Yu Wang +6 more
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Structure-function relationships in KDM7 histone demethylases
2019The demethylation of lysine residues of histone proteins is a key epigenetic mechanism in cells. The enzymes that catalyze these processes are called histone demethylases (KDMs). The largest family of KDMs is the Jumonji C (JmjC) domain-containing enzymes; these includes KDM2-7 subfamily of enzymes. The JmjC proteins are Fe(II) and 2-Oxoglutarate (2OG)
Shobhit S, Chaturvedi +4 more
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Dynamic and spatial restriction of Polycomb activity by plant histone demethylases
Nature Plants, 2018Wenhao Yan +9 more
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[Advances in histone methyltransferases and histone demethylases].
Ai zheng = Aizheng = Chinese journal of cancer, 2010Histone modification as one of the key epigenetic regulation mechanisms plays critical roles in various biological processes, including regulation of chromatin structure dynamics and gene expression. Both histone methyltransferase and histone demethylases contribute to the establishment and maintenance of different histone methylation status.
Xi, Wang, Wei-Guo, Zhu
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The emerging roles of histone demethylases in cancers
Cancer Metastasis ReviewD. Tong, Ying Tang, Peng Zhong
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