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Histone Demethylase KDM4A Regulates Histone Demethylation during Adipogenesis
, 2017 openaire +1 more source
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Profiling the Regulation of Histone Methylation and Demethylation by Metabolites and Metals
Methods in Molecular Biology, 2022Here we describe how to profile the contribution of metabolism and implication of metals to histone methylation and demethylation. The techniques described with the adequate protocols are metabolomics, quantitative proteomics, inductively coupled mass spectrometry and nanoscale secondary ion mass spectrometry.
Sebastian Müller +2 more
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Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4
Nature, 2010Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes to target gene repression by removing mono- and dimethyl marks from lysine 4 of histone H3 (H3K4).
Eric Metzger +2 more
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The Molecular Basis of Histone Demethylation
Cancer Drug Discovery and Development, 2017The methylation of lysine residues on histone tails--and their subsequent demethylation--is among some of the most important covalent post-translational modifications controlling gene expression. When gene expression goes awry, disease ensues and often this disease is some form of cancer.
John R Horton, Molly Gale, Qin Yan
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Neuroblastoma and Histone Demethylation
New England Journal of Medicine, 2018Histone Methylation in Neuroblastoma A recent study of inhibitors of histone demethylases in vitro and in an animal model of neuroblastoma underscores the potential of a new pharmacologic approach ...
Steven G, DuBois, Julie R, Park
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Histone demethylation and androgen-dependent transcription
Current Opinion in Genetics & Development, 2006Covalent modifications of histones play important roles in the regulation of chromatin dynamics and gene activity. Until recently, it was believed that methyl groups could not be removed from histones; as such, the discovery of the first demethylases opens a novel era in understanding how chromatin dynamic is regulated and shows that active ...
Metzger, Eric +2 more
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Enzymatic demethylation of calf thymus histones
Biochemical and Biophysical Research Communications, 1973Abstract Enzymatic demethylation of e-N-methyllysine residues of calf thymus histone has been investigated. Kidney contains the highest enzyme activity among the rat organs tested, and the enzyme activity is associated with the nuclear and mitocondrial fractions.
W K, Paik, S, Kim
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Histone Demethylation by Hydroxylation: Chemistry in Action
ACS Chemical Biology, 2006Histone methylation plays an essential role in epigenetic regulation and has been thought to be an irreversible and stable modification of histones. However, several enzymes have recently been discovered to demethylate mono- and dimethylated lysine residues of histone H3 as well as monomethylated arginines via either amine oxidation or deimination ...
Jessica, Schneider, Ali, Shilatifard
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