Results 181 to 190 of about 40,662 (194)

Histone demethylation and steroid receptor function in cancer

Molecular and Cellular Endocrinology, 2012
Steroid receptors recruit various cofactors to form multi-protein complexes which locally alter chromatin structure and control DNA accessibility in order to regulate gene transcription. Some of these factors are enzymes that add or remove histone marks in the vicinity of regulatory regions of target genes.
Antje, Stratmann, Bernard, Haendler
openaire   +2 more sources

Histone lysine methylation and demethylation pathways in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2011
The genetic changes leading to the development of human cancer are accompanied by alterations in the structure and modification status of chromatin, which represent powerful regulatory mechanisms for gene expression and genome stability. These epigenetic alterations have sparked interest into deciphering the regulatory pathways and function of post ...
Radhika A, Varier, H T Marc, Timmers
openaire   +2 more sources

8 Demethylation pathways for histone methyllysine residues

2006
Histone lysine methylation is one of the posttranslational modifications involved in transcriptional regulation and chromatin remodeling. The first lysine specific histone demethylase (LSD1) has been recently discovered, whichrules out the hypothesis that histone methylation represents a permanent epigenetic mark.
FORNERIS, FEDERICO, BINDA, CLAUDIA, Vanoni M. A., MATTEVI, ANDREA, Battaglioli E.   +4 more
openaire   +3 more sources

Histone demethylation by a family of JmjC domain-containing proteins

Nature, 2005
Covalent modification of histones has an important role in regulating chromatin dynamics and transcription. Whereas most covalent histone modifications are reversible, until recently it was unknown whether methyl groups could be actively removed from histones.
Yu-ichi, Tsukada, Jia, Fang, Hediye, Erdjument-Bromage, Maria E, Warren, Christoph H, Borchers, Paul, Tempst, Yi, Zhang   +6 more
openaire   +2 more sources

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

Nature Structural & Molecular Biology, 2007
Histone methylation regulates diverse chromatin-templated processes, including transcription. The recent discovery of the first histone lysine-specific demethylase (LSD1) has changed the long-held view that histone methylation is a permanent epigenetic mark.
Maojun, Yang, Jeffrey C, Culhane, Lawrence M, Szewczuk, Christian B, Gocke, Chad A, Brautigam, Diana R, Tomchick, Mischa, Machius, Philip A, Cole, Hongtao, Yu   +8 more
openaire   +2 more sources

Demethylation pathways for histone methyllysine residues

2006
Histone lysine methylation is one of the posttranslational modifications involved in transcriptional regulation and chromatin remodeling. The first lysine specific histone demethylase (LSD1) has been recently discovered, whichrules out the hypothesis that histone methylation represents a permanent epigenetic mark.
F. Forneris, C. Binda, M.A. Vanoni, A. Mattevi, E. Battaglioli   +4 more
openaire   +1 more source

What Is the Catalytic Mechanism of Enzymatic Histone N‐Methyl Arginine Demethylation and Can It Be Influenced by an External Electric Field?

Chemistry - A European Journal, 2021
Rajeev Ramanan, Sodiq O Waheed, Christopher J Schofield   +2 more
exaly  

Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase

Science, 2023
Fei Huang, Xiao Luo, Yang Ou
exaly  

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Nature, 2012
Chao Lｕ, Patrick S Ward, Gurpreet S Kapoor   +2 more
exaly  

Expression profiling of the Kdm genes in scallop Patinopecten yessoensis suggests involvement of histone demethylation in regulation of early development and gametogenesis

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2020
Lingling Zhang, Shaoxuan Wu, Shi Wang
exaly