Results 41 to 50 of about 40,662 (194)

Regulation of histone methylation by demethylimination and demethylation

Nature Reviews Molecular Cell Biology, 2007
Histone methylation has important roles in regulating transcription, genome integrity and epigenetic inheritance. Historically, methylated histone arginine and lysine residues have been considered static modifications because of the low levels of methyl-group turnover in chromatin.
Klose, R, Zhang, Y
openaire   +3 more sources

Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study. [PDF]

PLoS ONE, 2011
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a flavin-dependent amine oxidase which specifically demethylates mono- or dimethylated H3K4 and H3K9 via a redox process. It participates in a broad spectrum of biological
Xiangqian Kong, Sisheng Ouyang, Zhongjie Liang, Junyan Lu, Liang Chen, Bairong Shen, Donghai Li, Mingyue Zheng, Keqin Kathy Li, Cheng Luo, Hualiang Jiang   +10 more
doaj   +1 more source

Removal of H3K27me3 by JMJ Proteins Controls Plant Development and Environmental Responses in Arabidopsis

Frontiers in Plant Science, 2021
Trimethylation of histone H3 lysine 27 (H3K27me3) is a highly conserved repressive histone modification that signifies transcriptional repression in plants and animals.
Nobutoshi Yamaguchi
doaj   +1 more source

Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

Stem Cell Reports, 2018
Summary: Histone H3 lysine 9 (H3K9) methylation is unevenly distributed in mammalian chromosomes. However, the molecular mechanism controlling the uneven distribution and its biological significance remain to be elucidated.
Shunsuke Kuroki, Yuji Nakai, Ryo Maeda, Naoki Okashita, Mika Akiyoshi, Yutaro Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Ryuichiro Nakato, Kenji Ichiyanagi, Katsuhiko Shirahige, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana   +13 more
doaj   +1 more source

Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin

Journal of Hematology & Oncology, 2010
Background We have previously demonstrated that phenylhexyl isothiocyanate (PHI), a synthetic isothiocyanate, inhibits histone deacetylases and remodels chromatins to induce growth arrest in HL-60 myeloid leukemia cells in a concentration-dependent ...
Jiang Shaohong, Ma Xudong, Huang Yiqun, Xu Yunlu, Zheng Ruiji, Chiao Jen-Wei   +5 more
doaj   +1 more source

The effects of epigenetic modifiers on the differentiation of human dental pulp stem cells into neural progenitor-like cells

Advances in Biomedical and Health Sciences, 2023
Background: Human dental pulp stem cells (HDPSCs) may be differentiated into neural lineages. The main aim of the study was to assess the DNA demethylation and histone deacetylation inhibition on the differentiation of HDPSCs into neural progenitor-like ...
Fakhira Saif Alketbi, Amir Ali Khan, Muhammad Tehsil Gul, Muhammad Nasir Khan Khattak, Manju Nidagodu Jayakumar, A R Samsudin   +5 more
doaj   +1 more source

JmjC-domain-containing proteins and histone demethylation

Nature Reviews Genetics, 2006
Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system.
Klose, R, Kallin, E, Zhang, Y
openaire   +2 more sources

Chemical and biochemical approaches in the study of histone methylation and demethylation [PDF]

Medicinal Research Reviews, 2010
AbstractHistone methylation represents one of the most critical epigenetic events in DNA function regulation in eukaryotic organisms. Classic molecular biology and genetics tools provide significant knowledge about mechanisms and physiological roles of histone methyltransferases and demethylases in various cellular processes. In addition to this stream
Keqin Kathy, Li, Cheng, Luo, Dongxia, Wang, Hualiang, Jiang, Y George, Zheng   +4 more
openaire   +2 more sources

Increasing TET Expression and 5‐Hydroxymethylcytosine Formation by a Carbocyclic 5‐Aza‐2′‐deoxy‐cytidine Antimetabolite

Angewandte Chemie, EarlyView.
The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome‐wide demethylation and a surprisingly strong hydroxymethylation of cytosine, which translates into an efficient in vivo antitumor (AML) effect.
Maike Däther, Elsa Peev, Annika Fröhlich, Binje Vick, Sogol Fatourechi, Gilles Gasparoni, Matthias Heiss, Corinna C. Pleintinger, Emmanuel Asu Bisong, Hans Hurmiz, Davide Guglielminotti, Yasmin V. Gärtner, Tina Aumer, Karsten Spiekermann, Jörn Walter, Irmela Jeremias, Franziska R. Traube, Thomas Carell   +17 more
wiley   +2 more sources

The Histone H3K27 Demethylase REF6 Is a Positive Regulator of Light-Initiated Seed Germination in Arabidopsis

Cells, 2023
Seed germination is the first step in initiating a new life cycle in seed plants. Light is a major environmental factor affecting seed germination.
Yahan Wang, Dachuan Gu, Ling Deng, Chunmei He, Feng Zheng, Xuncheng Liu   +5 more
doaj   +1 more source