Results 31 to 40 of about 40,662 (194)
The role of demethylase AlkB homologs in cancer
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
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Biomolecules, 2022 Jumonji C (JmjC) lysine demethylases (KDMs) catalyze the removal of methyl (-CH3) groups from modified lysyl residues. Several JmjC KDMs promote cancerous properties and these findings have primarily been in relation to histone demethylation.
Anand Chopra +2 more
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Cell Reports, 2018 Summary: The arginine methylation status of histones dynamically changes during many cellular processes, including hematopoietic stem/progenitor cell (HSPC) development.
Sihui Li +20 more
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DNA Methylation Changes in Valproic Acid-Treated HeLa Cells as Assessed by Image Analysis, Immunofluorescence and Vibrational Microspectroscopy. [PDF]
PLoS ONE, 2017 Valproic acid (VPA), a well-known histone deacetylase inhibitor, has been reported to affect the DNA methylation status in addition to inducing histone hyperacetylation in several cell types.
Giovana M B Veronezi +4 more
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The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis [PDF]
The EMBO Journal, 2013 Histone chaperones affect chromatin structure and gene expression through interaction with histones and RNA polymerase II (PolII). Here, we report that the histone chaperone Spt6 counteracts H3K27me3, an epigenetic mark deposited by the Polycomb Repressive Complex 2 (PRC2) and associated with transcriptional repression.
A Hongjun, Wang +8 more
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Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells. [PDF]
PLoS ONE, 2013 Epigenetic gene silencing, mediated by aberrant promoter DNA hypermethylation and repressive histone modifications, is a hallmark of cancer. Although heritable, the dynamic nature and potential reversibility through pharmacological interventions make ...
Han Han +3 more
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Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. [PDF]
PLoS ONE, 2015 Epigenetic reprogramming is exemplified by the remarkable changes observed in cellular differentiation and X-chromosome inactivation (XCI) in mammalian female cells.
Yasunao F Kamikawa, Mary E Donohoe
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Cell Reports, 2014 Summary: Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.
Changmeng Cai +15 more
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Role of histone methylation and demethylation in adipogenesis and obesity [PDF]
Organogenesis, 2010 Adipocyte differentiation is a complex developmental process that involves the coordinated interplay of numerous transcription factors. PPARγ has emerged as a master regulator of adipogenesis and recent global target gene analysis demonstrated that PPARγ targets many genes encoding chromatin modification enzymes as well as genes of lipid metabolism and
Masashi, Okamura +3 more
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LSD1: more than demethylation of histone lysine residues [PDF]
Experimental & Molecular Medicine, 2020 AbstractLysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. In particular, it plays a special role in the epigenetic regulation of gene expression, as it removes methyl groups from mono- and dimethylated lysine 4 and/or lysine 9 on histone H3 (H3K4me1/2 and ...
Perillo Bruno +3 more
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