Effect of ribose-glycated BSA on histone demethylation [PDF]
Frontiers in Genetics, 2022 A reducing sugar reacts with the protein, resulting in advanced glycation end-products (AGEs), which have been implicated in diabetes-related complications.
Mengqi Xi +7 more
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Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation [PDF]
IUCrJ, 2014 Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent
Cheng Dong +2 more
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Histone H4K20 Demethylation by Two hHR23 Proteins [PDF]
Cell Reports, 2020 Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiaoyun Wang +2 more
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Primed histone demethylation regulates shoot regenerative competency [PDF]
Nature Communications, 2019 Plant regeneration can occur via formation of a mass of pluripotent cells known as callus. Here, Ishihara et al. show that acquisition of regenerative capacity of callus-forming cells requires a lysine-specific demethylase that removes H3K4me2 to prime ...
Hiroya Ishihara +15 more
doaj +6 more sources
Asparagine starvation suppresses histone demethylation through iron depletion [PDF]
iScience, 2023 Summary: Intracellular α-ketoglutarate is an indispensable substrate for the Jumonji family of histone demethylases (JHDMs) mediating most of the histone demethylation reactions.
Jie Jiang +13 more
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Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation
Cell Reports, 2021 Summary: Regulatory T (Treg) cells play crucial roles in suppressing deleterious immune response. Here, we investigate how Treg cells are mechanistically induced in vitro (iTreg) and stabilized via transcriptional regulation of Treg lineage-specifying ...
Beisi Xu, Minghong He, Xinying Zong
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Dissecting contributions of catalytic and reader domains in regulation of histone demethylation. [PDF]
Methods Enzymol, 2020 Histone demethylases catalyze the removal of methyl marks from histones, an activity associated with transcriptional regulation and DNA damage repair. As these processes are critical for normal physiology, deregulation of histone demethylases is disease causative, and their function and regulation are targets for therapeutic intervention. The larger of
Petronikolou N +2 more
europepmc +4 more sources
JmjC Histone Demethylases: Beyond Histone Lysine Demethylation
CHIMIAJumonji C histone lysine demethylases (JmjC-KDMs) are key chromatin regulators best known for catalysing histone lysine demethylation. There is growing evidence that JmjC-KDMs have a broader catalytic scope. This review summarises recent advances on JmjC-
Joanna Bonnici +2 more
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Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 [PDF]
Cell, 2004 Posttranslational modifications of histone N-terminal tails impact chromatin structure and gene transcription. While the extent of histone acetylation is determined by both acetyltransferases and deacetylases, it has been unclear whether histone methylation is also regulated by enzymes with opposing activities.
Yang Shi, Fei Lan, Peter Mulligan
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Histone Demethylation Profiles in Nonalcoholic Fatty Liver Disease and Prognostic Values in Hepatocellular Carcinoma: A Bioinformatic Analysis [PDF]
Current Issues in Molecular Biology, 2023 Yuanbin Liu, Mingkai Chen
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