Results 21 to 30 of about 40,662 (194)
The histone demethylase Jhdm1a regulates hepatic gluconeogenesis. [PDF]
PLoS Genetics, 2012 Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mellitus, this process is unrestrained and is a major contributor to fasting hyperglycemia.
Dongning Pan +6 more
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LSD1 and the chemistry of histone demethylation [PDF]
Current Opinion in Chemical Biology, 2007 The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the ...
Jeffrey C, Culhane, Philip A, Cole
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LSD1 demethylates histone and non-histone proteins [PDF]
Epigenetics, 2009 One of the key breakthroughs in the epigenetics/chromatin field in the last several years was the identification of enzymes capable of removing the methyl group from methylated lysines in histone proteins. Lysine-specific demethylase 1 (LSD1) was the first such enzyme identified, which has been shown to demethylate histone H3 on lysine 4 (H3K4) and ...
Thomas B, Nicholson, Taiping, Chen
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RTA promoter demethylation and histone acetylation regulation of murine gammaherpesvirus 68 reactivation. [PDF]
PLoS ONE, 2009 Gammaherpesviruses have a common biological characteristic, latency and lytic replication. The balance between these two phases in murine gammaherpesvirus 68 (MHV-68) is controlled by the replication and transcription activator (RTA) gene. In this report,
Zhangsheng Yang +3 more
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Functions and Interactions of Mammalian KDM5 Demethylases
Frontiers in Genetics, 2022 Mammalian histone demethylases of the KDM5 family are mediators of gene expression dynamics during developmental, cellular differentiation, and other nuclear processes.
Egor Pavlenko +4 more
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Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. [PDF]
PLoS ONE, 2010 Methylation of residues in histone tails is part of a network that regulates gene expression. JmjC domain containing proteins catalyze the oxidative removal of methyl groups on histone lysine residues.
Phillip Hahn +9 more
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Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro. [PDF]
PLoS ONE, 2013 Posttranslational modifications (PTMs) of the histone H3 tail such as methylation, acetylation and phosphorylation play important roles in epigenetic signaling.
Brian Lohse +6 more
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Histone Demethylation and Timely DNA Replication [PDF]
Molecular Cell, 2010 It is well-established that silent regions of the genome replicate late during S phase. In this issue of Molecular Cell, Black et al. (2010) uncover a conserved role for the JMJD2 family of histone demethylases in promoting replication within silent chromatin regions that contain histone H3 lysine 9 methylation and HP1.
Gerace, Erica L., Moazed, Danesh
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Structural insights into histone lysine demethylation [PDF]
Current Opinion in Structural Biology, 2010 Posttranslational modifications of histone tails are crucial epigenetic marks that regulate diverse cellular processes. Histone lysine methylation activates or represses transcription, depending on the site and degree of these modifications. Two classes of histone lysine demethylases remove histone methylation. Lysine demethylase 1 (KDM1, also known as
Haifeng, Hou, Hongtao, Yu
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Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b
Epigenetics & Chromatin, 2017 Background Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes.
Kevin T. Ebata +8 more
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