Results 11 to 20 of about 304,428 (339)

Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases

open access: yesEndocrine Journal, 2023
Autoimmune thyroid diseases (AITDs), such as Graves’ disease (GD) and Hashimoto’s disease (HD), are organ-specific autoimmune diseases. Histone acetylation, especially that of histone H3, is an epigenetic mechanism that regulates gene expression and is ...
Emi Haga   +8 more
doaj   +1 more source

Histone H3 Mutations in Cancer [PDF]

open access: yesCurrent Pharmacology Reports, 2018
Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation caused by alteration in chromatin-modifying enzymes has long been implicated in cancers. More recently, recurrent histone mutations have been identified in multiple cancers and have been shown to impede histone methylation ...
Yi Ching Esther Wan   +2 more
openaire   +3 more sources

Extracellular histone H3 facilitates ferroptosis in sepsis through ROS/JNK pathway

open access: yesImmunity, Inflammation and Disease, 2023
Introduction Previous evidence realized the critical role of histone in disease control. The anti‐inflammatory function of estradiol (E2) in sepsis has been documented.
Zhijun Han   +5 more
doaj   +1 more source

Nanoarchaeal Origin of Histone H3? [PDF]

open access: yesJournal of Bacteriology, 2009
ABSTRACTNEQ288, one of two archaeal histones inNanoarchaeum equitans, has a unique four-residue insertion that closely resembles an insertion in the eukaryotic histone H3 lineage. NEQ288 bound DNA but did not compact DNA in vitro in the absence of NEQ348, the secondN. equitansarchaeal histone.
John N. Reeve   +4 more
openaire   +3 more sources

JAK2 Gets Histone H3 Rolling [PDF]

open access: yesCancer Cell, 2009
Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 releases the transcriptional repressor HP1alpha from chromatin, resulting in gene transcription.
James D. Griffin   +2 more
openaire   +3 more sources

The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiae. [PDF]

open access: yesPLoS ONE, 2011
Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
Hiroshi Masumoto   +4 more
doaj   +1 more source

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

open access: yesChromosome Research, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3.
Earnshaw, W. C.   +56 more
openaire   +11 more sources

Histone H3 serine 57 and lysine 56 interplay in transcription elongation and recovery from S-phase stress. [PDF]

open access: yesPLoS ONE, 2010
BACKGROUND: Acetylation of lysine 56 of histone H3 plays an important role in the DNA damage response and it has been postulated to play an as yet undefined role in transcription, both in yeast and in higher eukaryotes.
Aamir Aslam, Colin Logie
doaj   +1 more source

Dual Roles of Extracellular Histone H3 in Host Defense: Its Differential Regions Responsible for Antimicrobial and Cytotoxic Properties and Their Modes of Action

open access: yesAntibiotics, 2022
Extracellular histones play a dual role—antimicrobial and cytotoxic—in host defense. In this study, we evaluated the antimicrobial and cytotoxic activities of histone H3 and identified the responsible molecular regions for these properties.
Yuri Tanaka   +6 more
doaj   +1 more source

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