Results 11 to 20 of about 196,399 (287)
The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
Hiroshi Masumoto +4 more
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Histone H3 serine 57 and lysine 56 interplay in transcription elongation and recovery from S-phase stress. [PDF]
PLoS ONE, 2010 BACKGROUND: Acetylation of lysine 56 of histone H3 plays an important role in the DNA damage response and it has been postulated to play an as yet undefined role in transcription, both in yeast and in higher eukaryotes.
Aamir Aslam, Colin Logie
doaj +1 more source
Antibiotics, 2022 Extracellular histones play a dual role—antimicrobial and cytotoxic—in host defense. In this study, we evaluated the antimicrobial and cytotoxic activities of histone H3 and identified the responsible molecular regions for these properties.
Yuri Tanaka +6 more
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Journal of Intensive Care, 2018 Background Nuclear histone proteins are released into the extracellular space during sepsis and act as major mediators of death. However, circulating histone levels have not been precisely quantified.
Takashi Ito +9 more
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Dynamic Histone H3 Modifications Regulate Meiosis Initiation via Respiration
Frontiers in Cell and Developmental Biology, 2021 Meiosis is essential for genetic stability and diversity during sexual reproduction in most eukaryotes. Chromatin structure and gene expression are drastically changed during meiosis, and various histone modifications have been reported to participate in
Jian Shi +6 more
doaj +1 more source
Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]
, 2013 Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin +7 more
core +1 more source
Reciprocal intronic and exonic histone modification regions in humans. [PDF]
, 2010 While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine +3 more
core +5 more sources
Thrombosis Journal, 2019 Background Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals.
Yayoi Yokoyama +7 more
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New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]
, 2008 The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin +8 more
core +1 more source
Poladenylated H3 histone transcripts and H3 histone vairants in alfalfa
Nucleic Acids Research, 1989 Histone H3 mRNAs were found in polyA(+) fractions of total RNA prepared from alfalfa plants, calli and somatic embryos. The sequence analysis of cDNAs revealed the presence of a polyA tail on independent alfalfa H3 mRNAs. A highly conserved sequence motif AAUGAAA identified about 20bp upstream from the 3' ends of the alfalfa H3 cDNAs was suggested to ...
S C, Wu, J, Györgyey, D, Dudits
openaire +3 more sources