Results 11 to 20 of about 304,428 (339)

Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases

Endocrine Journal, 2023
Autoimmune thyroid diseases (AITDs), such as Graves’ disease (GD) and Hashimoto’s disease (HD), are organ-specific autoimmune diseases. Histone acetylation, especially that of histone H3, is an epigenetic mechanism that regulates gene expression and is ...
Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe   +8 more
doaj   +1 more source

Histone H3 Mutations in Cancer [PDF]

Current Pharmacology Reports, 2018
Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation caused by alteration in chromatin-modifying enzymes has long been implicated in cancers. More recently, recurrent histone mutations have been identified in multiple cancers and have been shown to impede histone methylation ...
Yi Ching Esther Wan, Kui Ming Chan, Jiaxian Liu   +2 more
openaire   +3 more sources

Extracellular histone H3 facilitates ferroptosis in sepsis through ROS/JNK pathway

Immunity, Inflammation and Disease, 2023
Introduction Previous evidence realized the critical role of histone in disease control. The anti‐inflammatory function of estradiol (E2) in sepsis has been documented.
Zhijun Han, Zhizhou Yuan, Linfei Shu, Tao Li, Fan Yang, Lei Chen   +5 more
doaj   +1 more source

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

Science, 2001
J. Nakayama, J. Rice, B. Strahl, C. Allis, S. Grewal   +4 more
semanticscholar   +2 more sources

Nanoarchaeal Origin of Histone H3? [PDF]

Journal of Bacteriology, 2009
ABSTRACTNEQ288, one of two archaeal histones inNanoarchaeum equitans, has a unique four-residue insertion that closely resembles an insertion in the eukaryotic histone H3 lineage. NEQ288 bound DNA but did not compact DNA in vitro in the absence of NEQ348, the secondN. equitansarchaeal histone.
John N. Reeve, Harald Huber, Ulrike Friedrich-Jahn, Johanna Aigner, Gernot Längst   +4 more
openaire   +3 more sources

JAK2 Gets Histone H3 Rolling [PDF]

Cancer Cell, 2009
Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 releases the transcriptional repressor HP1alpha from chromatin, resulting in gene transcription.
James D. Griffin, James D. Griffin, Martin Sattler   +2 more
openaire   +3 more sources

The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2011
Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
Hiroshi Masumoto, Ryuichiro Nakato, Masato Kanemaki, Katsuhiko Shirahige, Mayumi Hachinohe   +4 more
doaj   +1 more source

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

Chromosome Research, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3.
Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H. A., Copenhaver, G. P., DeLuca, J. G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., Gorbsky, G. J., Harrison, Stephen, Heun, P., Hirota, T., Jansen, L. E. T., Karpen, G., Kops, G. J. P. L., Lampson, M. A., Lens, S. M., Losada, A., Luger, K., Maiato, H., Maddox, P. S., Margolis, R. L., Masumoto, H., McAinsh, A. D., Mellone, B. G., Meraldi, P., Musacchio, A., Oegema, K., O’Neill, R. J., Salmon, E. D., Scott, K. C., Straight, A. F., Stukenberg, P. T., Sullivan, B. A., Sullivan, K. F., Sunkel, C. E., Swedlow, J. R., Walczak, C. E., Warburton, P. E., Westermann, S., Willard, H. F., Wordeman, L., Yanagida, M., Yen, T. J., Yoda, K., Cleveland, D. W.   +56 more
openaire   +11 more sources

Histone H3 serine 57 and lysine 56 interplay in transcription elongation and recovery from S-phase stress. [PDF]

PLoS ONE, 2010
BACKGROUND: Acetylation of lysine 56 of histone H3 plays an important role in the DNA damage response and it has been postulated to play an as yet undefined role in transcription, both in yeast and in higher eukaryotes.
Aamir Aslam, Colin Logie
doaj   +1 more source

Dual Roles of Extracellular Histone H3 in Host Defense: Its Differential Regions Responsible for Antimicrobial and Cytotoxic Properties and Their Modes of Action

Antibiotics, 2022
Extracellular histones play a dual role—antimicrobial and cytotoxic—in host defense. In this study, we evaluated the antimicrobial and cytotoxic activities of histone H3 and identified the responsible molecular regions for these properties.
Yuri Tanaka, Nanako Yamanaka, Izumi Koyano, Itaru Hasunuma, Tetsuya Kobayashi, Sakae Kikuyama, Shawichi Iwamuro   +6 more
doaj   +1 more source