Results 271 to 280 of about 257,789 (305)
Some of the next articles are maybe not open access.
Targeting Histone Methylation in Cancer
The Cancer Journal, 2017Abstract Most, if not all, human cancers exhibit altered epigenetic signatures that promote aberrant gene expression that contributes to cellular transformation. Historically, attempts to pharmacologically intervene in this process have focused on DNA methylation and histone acetylation.
Michael T, McCabe +3 more
openaire +2 more sources
Histone methylation during neural development
Cell and Tissue Research, 2014Post-translational modification of histone proteins, such as the methylation of lysine and arginine residues, influences the higher order of chromatin and leads to gene activation or silencing. Histone methyltransferases or demethylases actively add or remove various methylation marks in a cell-type-specific and context-dependent way.
Roidl, Deborah, Hacker, Christine
openaire +3 more sources
The Sounds of Silence – Histone Deacetylation Meets hisTone Methylation
Genetica, 2003The repression of gene activity and the maintenance of the repressed state are fundamental requirements of cell differentiation, ordered embryonic development and tissue integrity. Furthermore, large regions of the genome such as centromeres and telomeres have a structural function and have to be kept transcriptionally inactive to be functional.
Birgit, Czermin, Axel, Imhof
openaire +2 more sources
Histone methylation in transcriptional control
Current Opinion in Genetics & Development, 2002Over the past year or so, methylation of histones has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyl-lysine 'mark' on histones.
openaire +2 more sources
Epigenetic regulation: methylation of histone and non-histone proteins
Science in China Series C: Life Sciences, 2009Histone methylation is believed to play important roles in epigenetic memory in various biological processes. However, questions like whether the methylation marks themselves are faithfully transmitted into daughter cells and through what mechanisms are currently under active investigation. Previously, methylation was considered to be irreversible, but
Fei, Lan, Yang, Shi
openaire +2 more sources
[Genomic DNA methylation and histone methylation].
Yi chuan = Hereditas, 2014DNA methylation is an important epigenetic marker in eukaryotes, and could affect chromatin structure and gene expression. With the development of genome-wide methylation sequencing technology, DNA methylation level in the whole genome can be evaluated.
Ruixian, Wang, Jianhong, Xu
openaire +1 more source
Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
exaly
Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease
Nature Reviews Drug Discovery, 2021Kamakoti P Bhat +2 more
exaly