Results 261 to 270 of about 245,589 (335)

Histone deacetylases and their co-regulators in Schizosaccharomyces pombe

, 2007
Rebecca A. Silverstein
openalex  

Influences of DNA Methylation and Histone Acetylation on Gene Expressions

Yu Wang
openalex   +2 more sources

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

SET7/9 exhibits sigmoidal kinetics on nucleosomes, hyperbolic kinetics on histones by an ordered sequential mechanism, and methylates lysine and arginine. [PDF]

J Biol Chem
Ige OO, Hendrickson-Rebizant T, Luo W, Cheung P, Lao Y, Zahedi RP, Davie JR, Lakowski TM.   +7 more
europepmc   +1 more source

Répression de l’expression génique contrôlée par l’ARN et les histones chaperonnes chez la levure fissipare Schizosaccharomyces pombe

, 2015
Matteo Cattaneo
openalex   +1 more source

Magnesium-Based Implants Accelerate Femoral Fracture Healing Through Promoting Histone Lactylation-Mediated Osteoclastogenesis Inhibition

Junyi Shen, Yilun Pei, Shangying Bai, Shan Lei, Shudong Xia, Jie Zhang, Xingyu Li, Hanchi Xu, Xinyu Zheng, Xuezhen Shen, Huijun Zhao, Liang Liu, Xinlin Yang, Xuefei Wang   +13 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

New leap of BRD9 inhibitor: Imidazole substituents making BRD9 inhibitors excellent drug candidates for AML. [PDF]

Acta Pharm Sin B
Zhou E.
europepmc   +1 more source

Existence of yeast genomic fragments hybridizing with the sea urchin histone H1 gene.

, 1994
George Miloshev, Jordanka Zlatanova
openalex   +2 more sources

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source