Results 261 to 270 of about 394,873 (373)
Advanced Science, EarlyView.This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin +7 more
wiley +1 more source
Palmitoyltransferase ZDHHC19 regulates histone-to-protamine exchange during spermiogenesis in mice. [PDF]
Sci AdvLi J +17 more
europepmc +1 more source
Relative Metabolic Activities of Histones in Tumours and Liver [PDF]
, 1960 J. A. V. Butler, D. J. R. Laurence
openalex +1 more source
Advanced Science, EarlyView.This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu +10 more
wiley +1 more source
Role of novel protein acylation modifications in sepsis. [PDF]
Front ImmunolWang J +6 more
europepmc +1 more source
From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies
Advanced Science, EarlyView.This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen +7 more
wiley +1 more source