Results 241 to 250 of about 183,055 (305)

Histone [PDF]

, 2019
openaire   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Nucleosome spacing across cell types, diseases, and ages. [PDF]

Nucleic Acids Res
Bikova M, Clarkson CT, Teif VB.
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Relationship of Circulatory Markers of NETosis with COVID-19 Severity: A Prospective Cohort Study. [PDF]

Indian J Crit Care Med
Kumar A, Kumar N, Banerjee A, Kumar A, Kumar A, Sinha C.   +5 more
europepmc   +1 more source

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

Advanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian, Zhenmin Le, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Chenyu Dong, Yetao Shen, Jiazheng Li, Yueping Ren, Xiaoyin Ma, Wei Chen, Qinxiang Zheng   +11 more
wiley   +1 more source

A method for cryo-EM analysis of eukaryotic nucleosomes reconstituted in bacterial cells. [PDF]

iScience
Ho CH, Kobayashi Y, Ogasawara M, Takizawa Y, Kurumizaka H.   +4 more
europepmc   +1 more source

Histone post-translational modifications of Leishmania braziliensis. [PDF]

Sci Data
de Almeida RF, Fernandes M, Figueiredo FB, de Godoy LMF.   +3 more
europepmc   +1 more source

Neutrophil Extracellular Traps in Dry Eye: A Comprehensive Review of Pathogenic Mechanisms and Implications for Targeted Therapy. [PDF]

Int J Gen Med
Guo X, Wang C, Liu W, Sun Y, Su L, Wang H, Liu B.   +6 more
europepmc   +1 more source

Neutrophil Extracellular Traps in Diabetic Kidney Disease: Mechanisms of Pathogenesis and Emerging Therapeutic Strategies. [PDF]

Drug Des Devel Ther
Wang B, Zhang R, Liu X, Shang Y, Jin T, Gao C, Yang N, Jin J, He Q.   +8 more
europepmc   +1 more source