Results 21 to 30 of about 543,356 (264)

Learning histopathological patterns

Journal of Pathology Informatics, 2012
The aim was to demonstrate a method for automated image analysis of immunohistochemically stained tissue samples for extracting features that correlate with patient disease. We address the problem of quantifying tumor tissue and segmenting and counting cell nuclei.Our method utilizes a flexible segmentation method based on sparse coding trained from ...
Kårsnäs, Andreas, Dahl, Anders Lindbjerg, Larsen, Rasmus   +2 more
openaire   +4 more sources

Clinical and prognostic profile of Her2neu positive (non-luminal) intrinsic breast cancer subtype: comparison with Her2neu positive luminal breast cancers

BMC Research Notes, 2018
Objective Her2neu receptor is proto-oncogene which can be over-expressed in both luminal and non-luminal breast cancers. In the present study, we aimed to compare the prognostic and predictive factors like tumor grade, T-stage, N-stage and ki67 index in ...
Atif Ali Hashmi, Raeesa Mahboob, Saadia Mehmood Khan, Muhammad Irfan, Mariam Nisar, Narisa Iftikhar, Maham Siddiqui, Naveen Faridi, Amir Khan, Muhammad Muzzammil Edhi   +9 more
doaj   +1 more source

Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation

World Journal of Surgical Oncology, 2023
Background Breast cancer is the most common tumor in women worldwide. Diabetes mellitus is a global chronic metabolic disease with increasing incidence. Diabetes mellitus has been reported to positively regulate the development of many tumors.
Xiao Cheng, Xiupeng Jia, Chunnian Wang, Shangyan Zhou, Jiayi Chen, Lei Chen, Jinping Chen   +6 more
doaj   +1 more source

Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer [PDF]

, 2019
Aims Lymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations.
Bartosch, Carla, Bosse, Tjalling, Genestie, Catherine, Lax, Sigurd F, McCluggage, W Glenn, Nout, Remi, Oosting, Jan, Peters, Elke E M, Singh, Naveena, Smit, Huub C S H, Smit, Vincent T H B M, Van de Vijver, Koen   +11 more
core   +2 more sources

Mismatch repair deficiency screening in colorectal carcinoma by a four-antibody immunohistochemical panel in Pakistani population and its correlation with histopathological parameters

World Journal of Surgical Oncology, 2017
Background Microsatellite instability (MSI) operates as the second major pathway in the colorectal carcinogenesis. Although genetic testing remains the gold standard for the detection of MSI, the College of American Pathologists (CAP) recommends an ...
Atif Ali Hashmi, Rabia Ali, Zubaida Fida Hussain, Naveen Faridi, Erum Yousuf Khan, Syed Muhammad Abu Bakar, Muhammad Muzzammil Edhi, Mehmood Khan   +7 more
doaj   +1 more source

Immune and genomic signatures in oral (head and neck) cancer

Heliyon, 2018
Head and neck squamous cell carcinoma (HNSCC) is responsible for a large number of deaths each year. Oral cancer is the most frequent subtype of HNSCC.
Prasenjit Chakraborty, Tanusri Karmakar, Neeraj Arora, Geetashree Mukherjee   +3 more
doaj   +1 more source

Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer

Breast Cancer Research, 2022
Background The effect of extracellular microenvironment (hypoxia and pH) has been regarded as a key hallmark in cancer progression. The study aims to investigate the effects of carbonic anhydrase IX (CAIX), a key hypoxia-inducible marker, in triple ...
Chong Hui Clara Ong, Dong Yeul Lee, Bernett Lee, Huihua Li, Jeffrey Chun Tatt Lim, Johnathan Xiande Lim, Joe Poh Sheng Yeong, Hiu Yeung Lau, Aye Aye Thike, Puay Hoon Tan, Jabed Iqbal   +10 more
doaj   +1 more source

PD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation. [PDF]

, 2016
A new approach to the management of non-small-cell lung cancer (NSCLC) has recently emerged that works by manipulating the immune checkpoint controlled by programmed death receptor 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1).
Booton, R, Cane, P, Cree, IA, Gosney, J, Ibrahim, M, Kerr, K, Lal, R, Lewanski, C, Navani, N, Nicholson, AG, Nicolson, M, Summers, Y   +11 more
core   +2 more sources

Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer. [PDF]

, 2012
BACKGROUND AND OBJECTIVES: Recurrence in lymph node-negative (pN0) colorectal cancer suggests the presence of undetected occult metastases. Occult tumor burden in nodes estimated by GUCY2C RT-qPCR predicts risk of disease recurrence.
Barkun, Alan, Hyslop, Terry, Schulz, Stephanie, Waldman, Scott A., Weinberg, David S.   +4 more
core   +2 more sources

The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome of invasive ductal breast carcinoma [PDF]

, 2007
Aims: To clarify MUC1 patterns in invasive ductal breast carcinoma and to relate them to clinicopathological parameters, coexpression of other biological markers and prognosis.
Arnerlov C, Berry N, Camp RL, Croce MV, Gendler S, Gendler SJ, Hayes DF, Hilkens J, Kohlgraf KG, Ligtenberg MJ, Wesseling J   +10 more
core   +2 more sources