Results 41 to 50 of about 423,247 (316)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Undifferentiated carcinoma of the liver with osteoclast-like giant cells: a case report and literature review

Infectious Agents and Cancer
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Osteoclast-like giant cells (OGCs) are relatively more common in pancreatic cancer, but extremely rare in HCC. Currently, there have been only a few reported cases of
Lixia Lu, Li Wang, Can Peng, Li Chen, Ximan He, Chenning Shao, Chunnian Wang, Rong Ge   +7 more
doaj   +1 more source

Epithelioid inflammatory myofibroblastic sarcoma – A rare case report

Human Pathology Reports
Inflammatory myofibroblastic tumors are mesenchymal neoplasms made up of spindle cells with inflammatory infiltrates and are intermediate-grade tumors.
Dona Maria George, Archana Lakshmanan, S Annapurneswari, Karuppasamy Usharani   +3 more
doaj   +1 more source

Frequency of Her2/Neu Immuno Histochemical Expression in Bladder Urothelial Carcinoma: A Study At CMH Quetta

Proceedings, 2022
Introduction: The staining pattern of HER2/Neu expression in urothelial bladder cancer has been established for more than a decade, and literature review of the past reveals a dismal prognosis in Her2/Neu expressed invasive urothelial carcinoma. Aims &
Javeria Faridi, Ahmed Ahson Khan, Ayesha Faridi, Sabeen Afshan, Umair Jan Bugti, Hassan Mumtaz   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Prediction of Kidney Histopathology.

, 2015
Subjects with a molecular score > Threshold I or > Threshold II were considered to be ≥ 3 or ≥ 4, respectively.*Histopathology grades were consistent with the predicted value using Threshold I.†Histopathology grades were consistent with the predicted ...
Kumiko Nishihara (789903), Takeshi Matsubara (150039), Shunsaku Nakagawa (430323), Eri Tomita (789905), Satohiro Masuda (647155), Hiroshi Yamada (565524), Atsushi Fukatsu (150086), Motoko Yanagita (134965), Moto Kajiwara (789906), Kazuo Matsubara (647154), Noriyuki Iehara (150080), Yoshinobu Igarashi (789907), Haruka Shinke (647149), Hitomi Miyata (789904)   +13 more
core   +1 more source

The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis [PDF]

, 2010
Background: Acute generalized exanthematous pustulosis (AGEP) represents a severe, acute, pustular skin reaction that is most often induced by drugs. AGEP can be difficult to differentiate from generalized pustular psoriasis (GPP) both clinically and ...
Fidler, Vaclav, Hilde Kuiper, Fidler, V., Vaclav Fidler, Kuiper, Hilde, Jonkman, M.F., Kardaun, Sylvia H., Kardaun, S.H., Jonkman, Marcel F., Marcel F. Jonkman, Kuiper, H., Sylvia H. Kardaun   +11 more
core   +2 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source