Results 1 to 10 of about 21,220 (243)
mBio, 2022 Intracellular pathogens residing within macrophage phagosomes are challenged with recognizing the phagosomal environment and appropriately responding to changing host defense strategies imposed in this organelle.
Stephanie C. Ray, Chad A. Rappleye
doaj +2 more sources
Phenotypic characterization of cryptic species in the fungal pathogen Histoplasma
mSphereHistoplasmosis is an endemic mycosis that often presents as a respiratory infection in immunocompromised patients. Hundreds of thousands of new infections are reported annually around the world.
Victoria E. Sepúlveda +4 more
doaj +3 more sources
PLoS Neglected Tropical Diseases, 2021 BackgroundHistoplasmosis is acquired by inhalation of spores of the dimorphic fungus Histoplasma spp. Although this pathogen is distributed worldwide, it is more prevalent in the Americas.
Natalia Rakislova +23 more
doaj +2 more sources
Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in the fungal pathogen Histoplasma. [PDF]
PLoS BiologyHeritable phenotypic switches are fundamental to the ability of cells to respond to specific conditions. Such switches are key to the success of environmental pathogens, which encounter disparate conditions as they transition between the environment and ...
Sarah Heater +4 more
doaj +2 more sources
Mapping Histoplasma spp. in bats and cave ecosystems: evidence from midwestern Brazil [PDF]
Applied and Environmental MicrobiologyCaves serve as natural reservoirs for diverse microbial species due to their unique biotic and abiotic conditions. Histoplasma spp. is frequently associated with guano-enriched soil, low luminosity, and high humidity, particularly in Latin America, a ...
João Paulo Romualdo Alarcão Bernardes +20 more
doaj +2 more sources
Genomic epidemiology of Histoplasma in Africa [PDF]
mBioHistoplasmosis, the disease caused by thermally dimorphic fungi in the genus Histoplasma, is usually associated with pulmonary involvement in healthy individuals and a disseminated syndrome in immunocompromised patients.
Rutendo E. Mapengo +15 more
doaj +2 more sources
Genome Sequences Reveal Cryptic Speciation in the Human Pathogen
mBio, 2017 Histoplasma capsulatum is a pathogenic fungus that causes life-threatening lung infections. About 500,000 people are exposed to H. capsulatum each year in the United States, and over 60% of the U.S. population has been exposed to the fungus at some point
Victoria E. Sepúlveda +4 more
doaj +2 more sources
Histoplasma Responses to Nutritional Immunity Imposed by Macrophage Activation
Journal of Fungi, 2019 The fungal pathogen Histoplasma capsulatum resides within the phagosome of host phagocytic cells. Within this intracellular compartment, Histoplasma yeast replication requires the acquisition of several essential nutrients, including metal ions.
Peter J. Brechting, Chad A. Rappleye
doaj +2 more sources
Elevated carbon dioxide enhances the growth and reduces the antifungal susceptibility of Histoplasma capsulatum [PDF]
Microbiology SpectrumHistoplasma capsulatum is a thermally dimorphic fungal pathogen. It causes approximately 500,000 infections annually in the United States. Histoplasma is present as avirulent mycelia in the soil and transforms into pathogenic yeasts at the human body ...
Qian Shen, Kelsey Steinmetz
doaj +2 more sources
Sensing the heat and the host: Virulence determinants of Histoplasma capsulatum
Virulence, 2019 Histoplasma capsulatum is a member of a group of fungal pathogens called thermally dimorphic fungi, all of which respond to mammalian body temperature by converting from an environmental mold form into a parasitic host form that causes disease ...
Sinem Beyhan, Anita Sil
doaj +2 more sources