Results 151 to 160 of about 659,648 (296)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

C & E Thayer Bank, Tillamook, Oregon, date unknown

, 1900
C & E Thayer Bank, Tillamook, Oregon, date unknown. The bank was owned and operated by Claudius and Estelle Bush Thayer. Estelle Bush Thayer was the daughter of Asahel Bush II who built Bush House.
unknown
core  

Climate-Driven Range Shifts Limit the Role of Non-Native Trees for Adaptation Processes of European Forests. [PDF]

Ecol Evol
Hazarika R, Chakraborty D, Vicente J, Vacik H.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Access to historic individually identifiable health information: a multi-institutional survey of research institutions. [PDF]

J Med Libr Assoc
Garfunkel A.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Impact of the neonatal intensive critical ultrasound workflow for managing neonatal acute pulmonary hypertension. [PDF]

Front Pediatr
Zheng M, Ling W, Zhang J, Ju R, Xiao T, Fu Y, Li B, Zheng Y, Wang J, Zhou X, Qin G, Zhong L, Zhu L, Hu Y, Zhang X, Ye Z, Li H, Liu Y, Wu N, Gao S, Hu X, Jiang Y, Luo X.   +22 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Timing of Orthostatic Blood Pressure Changes and Its Association With Orthostatic Symptoms and Falls at Very Old Ages: Findings From the ARIC Study. [PDF]

Hypertension
Khan MM, Larbi Kwapong F, Col H, Patil D, Zhang M, Turkson-Ocran RN, Ngo LH, Cluett JL, Mukamal KJ, Selvin E, Lutsey PL, Windham BG, Mosley TH, Hughes TM, Lipsitz LA, Valint A, Juraschek SP.   +16 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source