Results 141 to 150 of about 739,595 (343)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Transforming lives through archaeology: civil society, social justice and heritage
Internet ArchaeologyThis article discusses the need for protective factors for health and wellbeing through heritage and archaeology-led practice, and the range of benefits attributed to such practice in specific circumstances working with communities with unmet needs.
Linda Monckton
doaj +1 more source
1998 Guide to Funding Resources for Historic Preservation
, 1998 This document is a directory of potential funding sources for historic preservation and other related fields. Potential funding sources include national organizations, federal and state funds, regional funding sources, private foundations, corporate ...
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Legacy and Springboard: The Untapped Potential of Archaeological Archives for Scientific Innovation
Internet ArchaeologyArchaeological archives form a public resource that enables the reinterpretation of original findings from archaeological investigations, provides the raw material for further research, informs museum displays and teaching collections, and gives society ...
Barney Sloane
doaj +1 more source
Historical Explanation and Historical Names
RUDN Journal of Philosophy, 2015 The paper is dedicated to one of the aspects of the problem of the explanation in history, i.e. to an analysis of the contribution of references of names of historical persons, places, events etc. into an explanation in history. An important condition of explanation is the relevancy of what explains to what is explained. The latter is determined by the
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source