Results 121 to 130 of about 739,595 (343)

Detecting and understanding historic landscapes

Arqueología y Territorio Medieval, 2018
El libro Detecting and understanding historic lands- capes editado por Alexandra Chavarría Arnau y Andrew Reynolds, se construye a partir de 16 capítulos cuya temática conjunta versa sobre el tema de la International Summer School ‘Detecting and ...
Jesús Brufal Sucarrat
doaj  

Persistence in time: the hunt for Bacillus anthracis at a historic tannery site in Austria reveals genetic diversity thought extinct

Applied and Environmental Microbiology
Identifying and analyzing historic anthrax loci may provide a treasure trove to fill in the gaps of persistence in time and genetic diversity of Bacillus anthracis.
Maximilian F. Mayerhofer-Rochel, Florian Himmelbauer, Pierre Reinprecht, Sebastian Herndler, Hugo Weidinger, Hans-Jörg Hellinger, Michael P. Szostak, Gregor Grass, Monika Ehling-Schulz   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Paleoecology and taphonomy of an 18th-century landscape on the Southern High Plains of Texas (United States)

Frontiers in Ecology and Evolution
Whiskey Flats is a mid-18th-century archaeological site on the Southern High Plains of Texas, USA. The site is within Mustang Draw and composed of two areas.
Lila Jones, Eileen Johnson
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Post-Theory and Beyond

Revista Brasileira de Literatura Comparada
This article surveys and assesses the eclectic trends in literary theory and criticism in the posttheory age with a focus on three rubrics: the cultural turn, the historic turn, and the affective turn.
Luiz Fernando Valente
doaj  

Report and Recommendations on Strategies for Engaging Young Adults in the Historic Environment [PDF]

, 2009
This report is submitted by HEACS, the Historic Environment Advisory Council for Scotland, which was established in 2003 to provide Scottish Ministers with strategic advice on issues affecting the historic environment.
Silber, Evelyn, Noble, Ross, Johnson, Ian, Oram, Richard, Martin, Colin   +4 more
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