Results 71 to 80 of about 1,368,556 (344)

La problématique de l’utilisation des herbicides en foresterie: le cas du Québec

open access: yesVertigO, 2005
Herbicide use in forestry is analysed from an historical and  environmental perspective. First chemical herbicides were developed during the Second World War.
J. Fortier, C. Messier, L. Coll
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Towards National Archaeological Mapping. Assessing Source Data and Methodology—A Case Study from Scotland

open access: yesGeosciences, 2018
While the National Record of the Historic Environment (NRHE) in Scotland contains valuable information on more than 170,000 archaeological monuments, it is clear that this dataset is conditioned by the disposition of past survey and changing parameters ...
Łukasz Banaszek   +2 more
doaj   +1 more source

Urban Planning Regulations for Tourism in the Context of Overtourism. Applications in Historic Centres [PDF]

open access: gold, 2020
Manuel de la Calle Vaquero   +2 more
openalex   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

The Matrix: Connecting Time and Space in Archaeological Stratigraphic Records and Archives

open access: yesInternet Archaeology, 2020
The records of archaeological stratigraphic data and the relationships between stratigraphic units are fundamental to understanding the overall cohesiveness of the archaeological archive of an excavation.
Keith May
doaj   +1 more source

A tale of two cities: Annapolis and St. Augustine balancing preservation and community values in an era of rising seas [PDF]

open access: yes, 2020
Annapolis, Maryland, and St. Augustine, Florida, are colonial cities on the East Coast of the United States with national historic landmark designations recognizing the strong blends of natural and cultural resources that make each community unique ...
Craig, Lisa M., Keys, Leslee F.
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

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