Results 91 to 100 of about 739,595 (343)
The Impacts of Tourism on Cultural Identity on Lisbon Historic Neighbourhoods
, 2020 In the past last decades tourism was long perceived as a solution to remediate to economic crisis and recessions, while the impacts were secondary and weren’t qualified.
P. Daly, Á. Dias, M. Patuleia
semanticscholar +1 more source
Survey of Sustainable Regeneration of Historic and Cultural Cores of Cities
Energies, 2020 The united nations educational, scientific and cultural organization (UNESCO) considers the historic urban landscapes as the world heritages. Managing historic city centers and maintaining historic cores are the emerging challenges for sustainable urban ...
Mehrdad Chahardowli +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Geosciences, 2018 While the National Record of the Historic Environment (NRHE) in Scotland contains valuable information on more than 170,000 archaeological monuments, it is clear that this dataset is conditioned by the disposition of past survey and changing parameters ...
Łukasz Banaszek +2 more
doaj +1 more source
The Historic Urban Landscape approach to urban management: a systematic review
International Journal of Heritage Studies (IJHS), 2018 In 2011, UNESCO adopted the Historic Urban Landscape (HUL) recommendation and called for the application of a landscape approach to ensure the integration of cultural heritage policies and management concerns in the wider goals of sustainable urban ...
M. Ginzarly, C. Houbart, J. Teller
semanticscholar +1 more source
Journal of Cultural Heritage Management and Sustainable Development, 2020 PurposeThe main aim of this paper is to determine how well the UNESCO 2011 Recommendation on Historic Urban Landscape (hereafter, the HUL approach) is understood by the academic community today.
Julia Rey-Pérez, A. Roders
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source