Results 91 to 100 of about 659,648 (296)

Paleoecology and taphonomy of an 18th-century landscape on the Southern High Plains of Texas (United States)

Frontiers in Ecology and Evolution
Whiskey Flats is a mid-18th-century archaeological site on the Southern High Plains of Texas, USA. The site is within Mustang Draw and composed of two areas.
Lila Jones, Eileen Johnson
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Detecting and understanding historic landscapes

Arqueología y Territorio Medieval, 2018
El libro Detecting and understanding historic lands- capes editado por Alexandra Chavarría Arnau y Andrew Reynolds, se construye a partir de 16 capítulos cuya temática conjunta versa sobre el tema de la International Summer School ‘Detecting and ...
Jesús Brufal Sucarrat
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Historic Environment Fund Framework of Support

, 2016
The historic environment is a key component of our cultural heritage, contributing, through the archaeological heritage, architectural heritage, underwater heritage and historic landscapes to our sense of place and shared cultural identity.

core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

State Historic Preservation Office, application for Section 106 review

, 2020
□ □ □ □ □ STATE HISTORIC PRESERVATION OFFICE Application for Section 106 Review SHPO Use Only IN Received Date / / Log In Date / / OUT Response Date / / Log Out Date / / Sent Date / / Submit one copy for each project for which review is requested.
Michigan. State Historic Preservation Office
core  

The archetypal BMI distribution is symmetrical

Human Biology and Public Health
Background Currently used global standards and references for BMI are skewed to the right. We question that this feature reflects an archetypal human norm.
Christiane Scheffler, Theresia Nitschmann, Michael Hermanussen   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source