Results 81 to 90 of about 1,348,303 (315)

4th and Goal: What is the Interpretive Touchdown? [PDF]

open access: yes, 2012
What is the aim of historic interpretation? That seems like it would be a simple question to answer, but it\u27s simply not. Historic interpretation seems to be a many headed Hydra, with each interpreter seeing their own purpose and their own goals ...
Rudy, John M.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

'Do I really need to dig it?' — Making Choices in Development-Led Archaeological Excavation in Northern Ireland

open access: yesInternet Archaeology, 2018
Most excavations in Northern Ireland arise from new development or land-use change proposals. The requirement to mitigate usually results in an excavation of sub-surface remains, with a nuanced approach in dealing with urban, peri-urban and rural sites ...
John D.J. O'Keeffe
doaj   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Exploring general practice research in Germany: a systematic review of dissertation topics from 1965–2023

open access: yesScandinavian Journal of Primary Health Care
Background Since its academic inception in the 1960s, Germany’s general practice has seen numerous dissertations, many of which are housed in the ‘Archive of German language General Practice’ (ADAM).Aim This study aims to provide the first comprehensive ...
Nora Sosna, Jost Steinhäuser
doaj   +1 more source

Making Choices: Valletta, Development, Archaeology and Society

open access: yesInternet Archaeology, 2018
The European Archaeological Council's working group on 'Making Choices' conducted a survey of EAC member states about the ways in which they make decisions in archaeological heritage management with particular reference to development-led archaeological ...
Barney Sloane
doaj   +1 more source

Striking a Match in the Historic District: Opposition to Historic Preservation and Responsive Community Building [PDF]

open access: yes, 2007
In her 1981 Stanford Law Review article, Carol Rose articulated as a justification for the historic preservation vogue a community building rationale that transformed preservation from an end in itself to a means for community self-definition ...
Conde, Sarah N.
core   +1 more source

Historical Perspectives

open access: yes, 2010
The phenomenon of yawning is just as intriguing and fascinating as sleep, yet understanding of its causes and consequences has defied the human mind for centuries. Hippocrates, Sennert, Boerhaave and de Gorter each advanced a theory in his time. From the release of tainted humor to the awakening of animal spirits and improved brain oxygenation, the ...
openaire   +2 more sources

Home - About - Disclaimer - Privacy