Results 101 to 110 of about 1,526,402 (238)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

THE ROLE OF ETHICS AS A COMPONENT OF PHILOSOPHY IN HISTORY-THEMED DOCUMENTARIES

International Studies Journal
This article examines ethics and philosophical considerations in media and communication within the context of historical documentary filmmaking. The main aim is to speak to the reason for which history-themed documentaries as a form of film that deals ...
USAKU ROBINSON WAMMANDA
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Cloning, recombinant expression, and characterization of a Rhipicephalus microplus carboxylesterase. [version 1; peer review: 2 approved, 1 not approved]

Gates Open Research
Background The Rhipicephalus microplus carboxylesterase (CBE) is involved in synthetic pyrethroid (SP) hydrolysis and historic evidence suggests that a non-synonymous mutation (Asp374Asn) in CBE is associated with increased resistance towards SP-based ...
Michel Labuschagne
doaj   +1 more source

New Methods in Exploring Old Topics: Case Studying Brittle Diabetes in the Family Context

Journal of Diabetes Research, 2016
Background. In questing for a more refined quantitative research approach, we revisited vector autoregressive (VAR) modeling for the analysis of time series data in the context of the so far poorly explored concept of family dynamics surrounding instable
Moritz Philipp Günther, Peter Winker, Stefan A. Wudy, Burkhard Brosig   +3 more
doaj   +1 more source

Marges van de bouwhistorie

Bulletin KNOB, 2010
Although a considerable percentage of the practising building historians have an academic background, the origin of building history lies in the practical preservation of monuments and historic buildings.
Ronald Stenvert
doaj   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Autoridad e imagen de la epidemia. La fiebre amarillean la Barcelona del siglo XIX

Potestas. Estudios del Mundo Clásico e Historia del Arte, 2017
El propósito de este estudio es acercarse al contexto epidémico de Barcelona a lo largo del siglo XIX. De forma concreta, la investigación se centra en la fiebre amarilla sufrida en los años 1821 y 1870.
José Antonio Ortiz García
doaj   +1 more source

Sustainability of Buildings in Historic City of Malacca

, 2018
The paper discusses the sustainability of the buildings on the western side of the Historic City of Malacca with the help of the implementation of conservation policies.
W. Ismail
semanticscholar   +1 more source