Results 81 to 90 of about 34,682 (317)
RILEM Technical Letters, 2019 Built cultural heritage is at risk due to manmade and natural hazards. The seismic vulnerability of ancient masonry buildings is particularly difficult to assess and requires specialized technical skills.
Paulo Lourenco, Georgios Karanikoloudis
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Teaching and Research Tasks in the Pharmaceutical Services Profile in Cienfuegos in 2010
Medisur, 2011 Background: it is of utmost importance to conduct research to theoretically substantiate how to achieve a better academic and intellectual preparation of students.
Loreta Sánchez Ortiz +5 more
doaj +2 more sources
Educational role of public parks: windows to past, to future and to exotic worlds
4D, 2020 The design of public parks in Europe evolved at the end of 18th century. The first public parks were created primarily for leisure, entertainment and social representation.
Albert Fekete +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
TO THE SOURCES OF DIACHRONIC SOCIOLINGUISTICS: GLOBAL EXPERIENCE AND UKRAINIAN PROBLEMATICS
Записки з українського мовознавства, 2017 The subject of the suggested research is a new sphere of sociolinguistics – diachronic sociolinguistics: its sources, subject of the research and tasks.
І. Д. Фаріон
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
From Mexico to Mali: progress in health policy and systems research.
, 2008 In 2004, the ministerial summit in Mexico drew attention to the historic neglect of health policy and systems research (HPSR) and called for increased funding, investment in national institutional capacity for HPSR, and resources for selected priority ...
Evans, Tim +7 more
core +1 more source