Results 61 to 70 of about 482,315 (310)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Study on Input/Output Accounting Systems on EU agricultural holdings [PDF]

open access: yes, 2001
Of 241 questionnaires sent out to 20 countries 55 completed forms were returned. No information could be obtained about systems in Portugal or the USA.
Goodlass, G.   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Teaching and Research Tasks in the Pharmaceutical Services Profile in Cienfuegos in 2010

open access: yesMedisur, 2011
Background: it is of utmost importance to conduct research to theoretically substantiate how to achieve a better academic and intellectual preparation of students.
Loreta Sánchez Ortiz   +5 more
doaj   +2 more sources

Instrument or object? The New Zealand piano on display [PDF]

open access: yes, 2011
The piano is rather a unique display item in the museum or the historic house. Firstly, whether an upright or a grand, the piano is an imposing, substantial object that occupies significant space within a setting and immediately demands attention because
Moffat, Kirstine
core   +1 more source

Stinking Foreshore to Tree Lined Avenue: Investigating the Riverine Lives Impacted by the Construction of the Thames Embankments in Victorian London [PDF]

open access: yes, 2013
Victorian London saw dramatic physical changes along the river Thames. Large enclosed Docks and Thames Embankments were constructed as the city struggled to cope with its ballooning population and prospering shipping industry.
Steyne, H
core   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Seismic behavior and assessment of masonry heritage structures. Needs in engineering judgement and education

open access: yesRILEM Technical Letters, 2019
Built cultural heritage is at risk due to manmade and natural hazards. The seismic vulnerability of ancient masonry buildings is particularly difficult to assess and requires specialized technical skills.
Paulo Lourenco, Georgios Karanikoloudis
doaj   +1 more source

A Start to finish guide to opening a bed & breakfast: The business plan.

open access: yes, 2010
Background Beds and breakfast are the small business component of the hotel industry. Like all types of small businesses, many fail due to poor planning or misguided management. As more new entrepreneurs enter the market due to the decline of the economy
Fredette, Ellen A.
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

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