Results 71 to 80 of about 480,938 (253)

New Methods of Documenting the Past: Recreating Public Preaching at Paul's Cross, London, in the Post-Reformation Period [PDF]

, 2013
My goal is to develop a virtual research environment for study of the performance of sermons at Paul's Cross in the churchyard of St. Paul's Cathedral, England's most important public pulpit in the early modern period, where official religious policies ...
John N. Wall, John N. Wall
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

TO THE SOURCES OF DIACHRONIC SOCIOLINGUISTICS: GLOBAL EXPERIENCE AND UKRAINIAN PROBLEMATICS

Записки з українського мовознавства, 2017
The subject of the suggested research is a new sphere of sociolinguistics – diachronic sociolinguistics: its sources, subject of the research and tasks.
І. Д. Фаріон
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Più unica che rara: la genealogia della Vergine a sud delle Alpi. Tradizioni, committenze e canali di circolazione di un'insolita iconografia

Intrecci d'arte, 2015
The iconographic research deals with the particular topic of the Holy Kinship, a common subject in the north of the Alps, but almost absent in Italy.
Valeria Butera
doaj   +1 more source

Rights, Resources, Rezoning and the Challenges of Governance in South Africa's Oldest Marine Protected Area

Conservation & Society, 2020
This research examines the rezoning of Africa's oldest Marine Protected Area (MPA), the Tsitsikamma National Park (TNP) MPA. In December 2016, the TNP MPA was rezoned from 'no-take' to a partially open MPA to provide access for local fishing communities.
Ella-Kari Muhl, Merle Sowman
doaj   +1 more source

Retooling Waterfront Governance in the New York-New Jersey Harbor: Case Studies from Waterfront Cities [PDF]

, 2013
Who is in charge of the waterfront? Everybody and nobody. The scramble of commissions and task forces in the wake of Superstorm Sandy brought the challenge of waterfront governance into sharp relief.

core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source