Results 101 to 110 of about 2,696,748 (295)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Adapting historic sites: Konya-Sille's approach to climate resilience
Journal of Design for Resilience in Architecture and PlanningClimate change represents an increasingly significant threat worldwide, particularly affecting cities, with historic urban areas encountering this issue on a more profound and complex scale.
Murat Kitir
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
WEB GIS APPLICATIONS FOR THE HISTORIC SITES
Havacılık ve Uzay Teknolojileri Dergisi, 2013 Due to improvements on the technology, web-based Geographic Information Systems become an indispensable part of the projects. Because it provides accessibility, easy usage functions and effective sharing options, it can address to the public people, so ...
Mehmet Alkan +3 more
doaj
Cogent Social SciencesRecent years have witnessed a spurt of progress in China’s tourism industry, contributing greatly to the economy, culture, and ecology. Cultural relics and historic sites boast significant value in terms of tourism, economic, ecological service, cultural,
Jianing Lin +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The search for historical impact sites on Jupiter
Planetary and Space Science, 1996 Abstract A search was made through historical reports of major dark spots on Jupiter, recorded during the prephotographic era. While many of these reports meet the sufficient condition for impact candidacy (exogenic origin cannot be ruled out), the descriptions and drawings lack the detail required to meet the necessary condition (a morphology ...
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Historic Preservation League News
, 1992 Newsletter of the Dallas Historic Preservation League describing the group's activities, news, and events, as well as other preservation information of interest to ...
Dallas Historic Preservation League +1 more
core +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source