Results 81 to 90 of about 55,359 (280)
Auburn architectural survey : historic sites & structures inventory and planning recommendations
, 1983 This creative project consists of a historic sites and structures inventory and preservation planning recommendations for the town of Auburn, Indiana. It is prepared in a format similar to that of the Indiana Sites and Structures Inventories prepared for
Pedigo, Bryant C.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Interventions in Historic Urban Sites After Earthquake Disasters
ArchitectureEarthquakes, fires, and climate change-related hazards increasingly threaten cultural heritage. Documenting and identifying the significance of heritage sites before disasters is essential for archival purposes and for guiding post-disaster interventions
Hatice Ayşegül Demir +1 more
doaj +1 more source
Historic Sites photograph collection [DIGITAL CONTENT]
This collection contains photographs of historic sites in ...
Central Arkansas Library System. Butler Center for Arkansas Studies. (Little Rock, Ark.)
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
An historical archaeological site.
Clio: Revista de Pesquisa Histórica, 1980 An historical archaeological site.
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Adapting historic sites: Konya-Sille's approach to climate resilience
Journal of Design for Resilience in Architecture and PlanningClimate change represents an increasingly significant threat worldwide, particularly affecting cities, with historic urban areas encountering this issue on a more profound and complex scale.
Murat Kitir
doaj +1 more source