Results 71 to 80 of about 55,359 (280)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Salvaging historic shipwrecks in South Africa
, 2013 Includes bibliographical referencesThe mystique surrounding shipwrecks has intrigued man since the inception of sea travel itself. The wreck lies as a submerged time capsule, holding secrets of the past, patiently waiting to tell her stories, with rich ...
Newdigate, James
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Ochrona Dziedzictwa Kulturowego, 2016 In Poland, protection of historic monuments and sites is nearly one hundred years old and it has got a highly distinctive feature – the more recent the events are, the more frequent and more profound changes can be observed; the most significant ones ...
Jacek Dąbrowski
doaj +1 more source
Historical, architectural, and archaeological survey of Orlando, Florida.
, 1978 Report of a survey of historic and archaeological sites conducted to provide an inventory to be used as a resource for preservation planning.https://stars.library.ucf.edu/floridaheritage/1039/thumbnail ...
Werndli, Phillip A., +2 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Specifying the Significance of Historic Sites in Heritage Planning
Conservation Science in Cultural Heritage, 2018 Heritage planning is the preservation, conservation, rehabilitation, restoration and management of heritage resources. This paper aims to propose an approach for specifying the values and importance of historic sites.
Ahmadreza Shirvani Dastgerdi +1 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source