Results 91 to 100 of about 2,696,748 (295)
Historical, architectural, and archaeological survey of Orlando, Florida. [PDF]
, 1978 Report of a survey of historic and archaeological sites conducted to provide an inventory to be used as a resource for preservation planning.https://stars.library.ucf.edu/floridaheritage/1039/thumbnail ...
Werndli, Phillip A., +2 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Analysis of historic rammed earth construction [PDF]
, 2008 Rammed earth is an ancient construction technique which has recently become popular for sustainable building. Soil is compacted in removable formwork to make a homogeneous wall.
Jaquin, Paul A.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Interventions in Historic Urban Sites After Earthquake Disasters
ArchitectureEarthquakes, fires, and climate change-related hazards increasingly threaten cultural heritage. Documenting and identifying the significance of heritage sites before disasters is essential for archival purposes and for guiding post-disaster interventions
Hatice Ayşegül Demir +1 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Geomorphic Settings of Known Archaeological Sites in the Lower Grand River Valley, Ottawa County, Michigan [PDF]
, 2010 To predict undiscovered archaeological sites in the Lower Grand River, we mapped known archaeological sites using color and infrared aerial photos, digital raster graphics, and digital elevation models.
Hansen, Nathaniel J.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Preliminary Condition Analysis of Samadhi Dewan Sawan Mal, Multan
Sir Syed University Research Journal of Engineering and Technology, 2021 Historic structures are unparalleled jewels of the past embedded in the built environment. They integrate the present society with the past and future through its historic fabric existence over the decades.
Jahanzaib Qamar +2 more
doaj