Results 51 to 60 of about 7,049,835 (311)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Vygotsky in applied neuropsychology

open access: yesPsychology in Russia: State of Art, 2016
The aims of this paper are: 1) to show the role of clinical experience for the theoretical contributions of L.S. Vygotsky, and 2) to analyze the development of these theories in contemporary applied neuropsychology.
Glozman J. M.
doaj   +1 more source

Determination of the Recreational Landscape Potential of Tarsus (Mersin) District and Its Surroundings for Tourism

open access: yesJournal of Architectural Sciences and Applications, 2023
The study conducted an investigation into the effective utilization of Tarsus district's historical and cultural assets in Mersin province, with a focus on its tourism potential.
Elif Akpınar Külekçi, Sümeyye Gencer
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Effectiveness of Task-Based Learning in Historical and Cultural Research Method Classes

open access: yesQalamuna, 2022
This study analyzes the effectiveness of task-based learning in the History and Culture Research Methods class. This approach focuses on engaging students through goal-oriented assignments that are relevant to real life.
Yessy Harun, Febi Nur Biduri
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Living Subjectivity and Cultural-historical Method: Limits to Applicability

open access: yesВестник Московского университета. Серия 14: Психология, 2023
Background. Any method of research or influence has limits of applicability. Determining the limits of applicability of the cultural-historical approach will reveal new phenomena in the study of living subjectivity that cannot be investigated within the ...
Eugene V. Subbotsky
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Методологические подходы в междисциплинарных исследованиях истории библиотечного дела

open access: yesБиблиосфера, 2011
The methodological approaches in interdisciplinary researches of library activities history - historical and cultural, regional, historical and library science are considered.

doaj  

Home - About - Disclaimer - Privacy