Results 51 to 60 of about 7,049,835 (311)
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Vygotsky in applied neuropsychology
The aims of this paper are: 1) to show the role of clinical experience for the theoretical contributions of L.S. Vygotsky, and 2) to analyze the development of these theories in contemporary applied neuropsychology.
Glozman J. M.
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The study conducted an investigation into the effective utilization of Tarsus district's historical and cultural assets in Mersin province, with a focus on its tourism potential.
Elif Akpınar Külekçi, Sümeyye Gencer
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We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Effectiveness of Task-Based Learning in Historical and Cultural Research Method Classes
This study analyzes the effectiveness of task-based learning in the History and Culture Research Methods class. This approach focuses on engaging students through goal-oriented assignments that are relevant to real life.
Yessy Harun, Febi Nur Biduri
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Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Living Subjectivity and Cultural-historical Method: Limits to Applicability
Background. Any method of research or influence has limits of applicability. Determining the limits of applicability of the cultural-historical approach will reveal new phenomena in the study of living subjectivity that cannot be investigated within the ...
Eugene V. Subbotsky
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Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Методологические подходы в междисциплинарных исследованиях истории библиотечного дела
The methodological approaches in interdisciplinary researches of library activities history - historical and cultural, regional, historical and library science are considered.
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