Results 71 to 80 of about 194,482 (300)

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Cultural-Historical Foundations of School Course in Biology

open access: yesПсихологическая наука и образование, 2020
The article analyzes the provisions of the cultural-historical psychology that serve as a theoretical and methodological basis for the practice of general education in biology.
Suchorukova L.N., Isaev E.I.
doaj   +1 more source

Solovki as an object of cultural heritage of the Arctic [PDF]

open access: yesАрктика и Север, 2017
Solovki as a multi-subject object of cultural and natural heritage of the Arctic is one of the unique monuments of our time, bringing together at one place several historical periods of life in Russia.
Yury F. Lukin
doaj   +1 more source

Cultural-historical psychology and the activity approach in the studies of modern education: сomments

open access: yes, 2017
With reference to the Presentation of the colleague Lucisano of the Sapienza University, the author stresses the still great meaning of the KIP by Vygotskij for a correct understanding of today’s needs for education and instruction in Europe.
Veggetti M.S.,, S.M. Veggetti
core   +1 more source

HISTORICAL AND CULTURAL APPROACH TO THE PROCESS OF STUDYING OF GENERAL PEDAGOGICAL DISCIPLINES

open access: yesEUREKA: Social and Humanities, 2018
The article analyzes the historical and cultural approach to the implementation of the principle of historicism to resolve the educational and breeding problems. It defined the components, which forms the methodological culture taking into account the innovative ideas and values from the past periods of educational thought development in Ukraine.
openaire   +3 more sources

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

DEVELOPMENT AND LEARNING OF STUDENTS WITH DISABILITIES: SUPPORT THE CULTURAL- HISTORICAL APPROACH [PDF]

open access: yes, 2012
Este artigo busca tecer correlações entre as práticas de inclusão de alunos com algum tipo de deficiência em escolas comuns e os pressupostos da abordagem histórico-cultural. Para tanto, construímos a argumentação a partir da discussão sobre as premissas
BERNAL, CÍNTIA DE MENEZES FERNANDES
core   +1 more source

Shapes of Clay Vessels As a Subject of Study. Historical-and-Cultural Approach.

open access: yesФОРМЫ ГЛИНЯНЫХ СОСУДОВ КАК ОБЪЕКТ ИЗУЧЕНИЯ, 2018
Сборник состоит из двух частей. Первая часть содержит статьи выдающегося советского и российского археолога-керамиста А.А. Бобринского, посвященные методам изучения форм глиняных сосудов и изданные в 1986–1999 гг., а также неопубликованную статью 1984 г.
openaire   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Vygotsky in applied neuropsychology

open access: yesPsychology in Russia: State of Art, 2016
The aims of this paper are: 1) to show the role of clinical experience for the theoretical contributions of L.S. Vygotsky, and 2) to analyze the development of these theories in contemporary applied neuropsychology.
Glozman J. M.
doaj   +1 more source

Home - About - Disclaimer - Privacy