Results 91 to 100 of about 7,049,835 (311)

FESTIVALS AS DRIVERS OF CREATIVE INDUSTRY DEVELOPMENT: HISTORICAL AND CULTURAL APPROACH

, 2022
The purpose of the article is to analyse the current research problems on festivals as drivers of the development of creative industries in the context of historical and cultural approaches. The article reveals the theoretical and methodological foundations of the development of festivals in the late 20th and early 21st century in cultural thought ...
openaire   +3 more sources

Michael Cole as the Mediator and Integrator of Cultural-Historical Psychology

Культурно-историческая психология, 2018
The article describes the ideas and tuning points of M. Cole's career — the famous American psychologist, his theoretical, methodological and empirical contribution to modern psychology. It is composed of three sections.
Meshcheryakov B.G.,, Ponomarev I.V.,
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Human development: a cultural approach. Australian and New Zealand edition

, 2018
This text helps students understand how culture impacts development — and why it matters. Human Development: A Cultural Approach leads students to examine all stages of development through the engaging lens of culture.
Brownlow, Charlotte, Arnett, Jeffrey, Chapin, Laurie   +2 more
core  

Technology of Production of Ceramics of the Andronovo (Fedorovo) Culture of the Steppe and Forest-Steppe Altai (on the materials of research of the historical and cultural approach)

Teoriya i praktika arkheologicheskikh issledovaniy, 2021
Based on the analysis of publications devoted to the study of ceramics of the Andronovo (Fedorovo) culture of the steppe and forest-steppe Altai, the article considers the peculiarities of pottery production, studied within the framework of the historical and cultural direction developed by A. A. Bobrinsky.
openaire   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Differentiated approach to teaching students to make historical and cultural comments with the help of the Internet resources

Literature at School, 2020
The purpose of the study was to create a methodological model of a differentiated learning process while making historical and cultural comments during the lessons in Literature and Literature-based reading. The differentiated approach should take into account not only the age, personal, psychological, and pedagogical characteristics of students, but ...
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Models of cultural niche construction with selection and assortative mating

, 2012
This research was supported in part by National Institutes of Health grant GM28016 and a Biotechnology and Biological Sciences Research Council studentship to LF. The funders had no role in study design, data collection and analysis, decision to publish,
Fogarty, Laurel, Creanza Nicole, Marcus W. Feldman (143724), Laurel Fogarty (143721), Fogarty Laurel, Feldman Marcus W., Laurel Fogarty, Nicole Creanza (143720), Feldman, Marcus W., Creanza, Nicole, Marcus W Feldman, Nicole Creanza   +11 more
core   +1 more source