Results 91 to 100 of about 194,482 (300)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An Attempt to the Systematization of Essentials Contents of Historical Cultural Approach
Psicologia, 2005 This article intends to present trial systematization and the general concepts of Historical Cultural Approach content’s, considering its beginning. The article presents several reflections about the reasons that allow considering the historical cultural
Guillermo Arias Beatón
doaj
Active Teaching Approach: Teaching and Learning Methods on Historical and Cultural Theory
Creative Education, 2014 This study is a theoretical synthesis of researches performed in the scholar context aiming to present an active teaching and learning proposal that sees teaching approach as the dialectical unity in concepts of internalization movement. The actions are organized by the professor and carried out by the subjects who are actively involved in the ...
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Cultural Historical Approach to Social Displacement and University-Community Engagement : Emerging Research and Opportunities, by C. Underwood, M. Welsh Mahmood and O. Vásquez. IGI Global, 2021, 300 pp. [PDF]
Book reviewUnderwood, C., Mahmood, M. W., & Vásquez, O. (2021). A Cultural Historical Approach to Social Displacement and University-Community Engagement: Emerging Research and Opportunities. IGI Global.
Kajamaa, Anu, Tuunainen, Juha
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
FESTIVALS AS DRIVERS OF CREATIVE INDUSTRY DEVELOPMENT: HISTORICAL AND CULTURAL APPROACH
, 2022 The purpose of the article is to analyse the current research problems on festivals as drivers of the development of creative industries in the context of historical and cultural approaches. The article reveals the theoretical and methodological foundations of the development of festivals in the late 20th and early 21st century in cultural thought ...
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Literature at School, 2020 The purpose of the study was to create a methodological model of a differentiated learning process while making historical and cultural comments during the lessons in Literature and Literature-based reading. The differentiated approach should take into account not only the age, personal, psychological, and pedagogical characteristics of students, but ...
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Digital Presentation and Preservation of Cultural and Scientific Heritage, 2015 This paper discusses an implementation of a multimedia projection system with two synchronized video sources, based on the Raspberry Pi single board computer systems. The system is primarily intended for various projections in presentation of historical and cultural heritage, although it can be used for many other related purposes.
D. Savić, Nemanja +2 more
openaire +3 more sources