Results 111 to 120 of about 194,482 (300)

Specific Characteristics of the Classification of Historical and Cultural Heritage Objects

, 2023
The article reflects on the separation of the absolute difference of objects, despite the different points of view and approaches to the classification of historical-cultural heritage. Also, in the study of historicalcultural heritage, the most important
Khoshimov, I. (Ilkhom)
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The dual impact of digital humanities: evaluating the role of DH approaches in historical and cultural resource development

Information Research an international electronic journal
Purpose. Digital humanities (DH) approaches have irreversibly impacted historical and cultural resource development. This study critically examines the dual impact of DH approaches to highlight their contributions and limitations in resource preservation and enhancement. Method.
Sijia Lu, Jiaqing Long, Yongjun Xu
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Web based Application for Presentation of Bulgarian Cultural and Historical Heritage under the Protection of UNESCO

Digital Presentation and Preservation of Cultural and Scientific Heritage, 2019
The paper briefly describes the web based application “Me and UNESCO” for the realization of the database “Bulgarian cultural and historical heritage under the protection of UNESCO”, developed in IMI (BAS).
Stefka Kovacheva, Ludmila Dimitrova
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Ontological approach to consolidation of 3D models of objects of historical and cultural heritage and GIS

Радіоелектронні і комп'ютерні системи, 2021
The development of the information society, the rise of the knowledge economy, the implementation of the latest technologies in the IT industry have provided the opportunity for free mass access to the digitized heritage of world civilization using augmented and virtual reality in three-dimensional space.
openaire   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Response to Commentary “Cultural-Historical Neuropsychology and ADHD” by Prof. Tatiana V. Akhutina

Культурно-историческая психология
The present short review contains the authors response to Commentary “Cultural-Historical Neuropsychology and ADHD” by Prof. Tatiana V.
A. Koutsoklenis, Y. Solovieva, L. Quintanar   +2 more
doaj   +1 more source