Results 121 to 130 of about 7,049,835 (311)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reflection 3

, 2009
ICIS Peripheral Project,The Historical,Geographical and Anthropological Research School of Thanh Ha in the Outer Port of Hue,Vietnam, Column1:To Read with the Heart or from the Face?, The Second ICIS International Symposium Construction of Cultural ...
4738, Institute, For Cultural Interaction Studies Kansai University, 4742   +2 more
core  

The life cycle approach as an innovative methodology for the recovery and restoration of cultural heritage

, 2014
Purpose – In this paper, of exploratory character, the purpose of this paper is to propose the analysis of the life cycle for assessing the environmental, economic, and social impact in the activity of recovery, restoration, and valorization of ...
Pini M., García, José Francisco, Ferrari A. M., Fernández del, Hoyo Alfonso Pedro, PINI, MARTINA, Settembre, Blundo Davide, SETTEMBRE BLUNDO, DAVIDE, Fernández del Hoyo A. P., FERRARI, Anna Maria, Riccardi, Maria Pia, García J. F.   +10 more
core   +1 more source

Historical consciousness and strategies of detraumatization of historical culture in the modern world

Studia Humanitatis, 2019
The article presents the socio-philosophical analysis of detraumatization and its main strategies in modern historical culture. Detraumatization was interpreted as the cultural practice of reformatting the semantic structure of relations between the past
Linchenko Andrei Aleksandrovich
doaj  

PROBLEMS OF IDENTIFICATION AND THE FORMATION OF TOURIST-RECREATIONAL CLUSTERS

Вестник Северо-Кавказского федерального университета, 2022
The essence of tourism and recreation cluster. We analyze the algorithm and the method of identification of tourist and recreational clusters in the region.
Irina V. Novikova
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Linking pattern to process in cultural evolution: explaining material culture diversity among the Northern Khanty of Northwest Siberia

, 2009
Book description: This volume offers an integrative approach to the application of evolutionary theory in studies of cultural transmission and social evolution and reveals the enormous range of ways in which Darwinian ideas can lead to productive ...
Jordan, P.
core  

The cultural-historical approach as the basis of a methodology for strategic learning of writing in a foreign language

Revista MENDIVE, 2007
The historical-cultural approach is one of the most influential psychological theories nowadays. Foreign language teaching-learning has not been away from this influence.
Vilma María Pérez Viñas
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source