Results 81 to 90 of about 7,049,835 (311)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Culture-led Urban Regeneration- An Example from Zong-Ye Historical District in Tainan [PDF]
The impacts of globalization force Asian countries face the problems of transformation, this paper aim to discuss how to keep the local identification and cultural characteristic under the wave of globalization.
Chengche Chen, Hsienhsin Cheng
core
From cultural studies to cultural science
, 2009 This paper, first presented at a symposium on the 'past, present and future of cultural studies,' traces disciplinary changes in the study of culture from the perspective of 'cultural science', a term that was used by some of the earliest practitioners ...
John Hartley +2 more
core +1 more source
The Psychological Content of Relationship between Sense and Meaning in Cultural-Historical Approach
Культурно-историческая психология, 2018 The paper considers L.S. Vygotsky’s cultural-historical theory and its interpretation in modern psychology. It shows that psychological content of many concepts introduced by L.S. Vygotsky differs greatly from that of the ones used in theory and practice
Kravtsova E.E., , Kravtsov G.G.,
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
, 2010 To what extent can we know past and mainly invisible landscapes, and how we can use this still hidden knowledge for actual sustainable management of landscape’s cultural and historical values.
Kars, H. +3 more
core
Cultural Dimension of the Communist Party in Manzanillo (1925-1935)
Santiago, 2015 The present research work, a partial result of a scientific project, allows an approach to the activity of Manzanillo communists during the stage from 1925 to 1935.
MSc. Aida Mercedes Sera-Fernández
doaj
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2015 This paper discusses an implementation of a multimedia projection system with two synchronized video sources, based on the Raspberry Pi single board computer systems. The system is primarily intended for various projections in presentation of historical and cultural heritage, although it can be used for many other related purposes.
Nemanja D. Savić +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source