Results 81 to 90 of about 194,482 (300)

The cultural biography of a street. Memory, cultural heritage and historical notion of the Visserstraat in Breda, the Netherlands (1200-2000) [PDF]

, 2014
Presented in this article is a scheduling principle that can be used to improve the practicalapproach to cultural history. In short, it means operationalising the three time levels of Fernand Braudel to form a conceptual-historical approach.
Wim Hupperetz, Hupperetz, W.
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Dialectical and historical method, cultural-historical theory and education: some appropriation in research on education of teachers who teach mathematics [PDF]

, 2016
The contributions of the cultural-historical approach to the comprehension of phenomena related to learning processes and human development have been expressed in the increasing number of academic research that take such approach as theoretical reference.
Martins, Edna, Moretti, Vanessa Dias, de Souza, Flávia Dias   +2 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

ADHD Diagnosis from the Perspective of Cultural-Historical Neuropsychology

Культурно-историческая психология
The diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD) has been a subject of enduring debates, with numerous discussions challenging its validity and questioning the evidence that supports its existence.
A. Koutsoklenis, Y. Solovieva, L. Quintanar   +2 more
doaj   +1 more source

Marxism, Cultural Studies, and the “Principle Of Historical Specification”: On The Form of Historical Time in Conjunctural Analysis

Lateral, 2018
Karl Korsch identifies in Marx’s work what he calls “the principle of historical specification,” the way in which “Marx comprehends all things social in terms of a definite historical epoch.” This work is concerned with this idea and its instantiation in
Douglas Spielman
doaj   +1 more source

Narrative as Cultural Mediator in Personality Development: Looking through the Lens of Cultural-Historical Psychology

Культурно-историческая психология, 2016
The article considers the features of the narrative approach as a new methodology for the study of personality and its development mechanisms. The article discusses the basic settings of social constructionism, in which most of the narrative research are
Turusheva Y.B.,
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

HUMAN DEVELOPMENT, COGNITION AND SCHOOL EDUCATION: REFLECTIONS BELOW THE HISTORICAL-CULTURAL APPROACH

Reflexão & Ação, 2016
This text is fruit of studies, reflections and dialogues developed with graduate and post-graduate students inteaching and research coordinated by me, allocated in the research group: Human Development, Culture and Education, in rows : Language, Learning
Solange Maria Alves
doaj   +1 more source