Results 151 to 160 of about 140,262 (309)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

CULTURAL TOURISM IN A GREEK INSULAR COMMUNITY: THE RESIDENTS’ PERSPECTIVE

open access: yes
Cultural tourism constitutes an alternative strategy of sustainable local development for improving quality of life. The main objective of this type of tourism is to transform the regions, which are characterized by cultural resources, into ideal places ...
Sdrali, Despina, Chazapi, Katerina
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

The historical imagination of Christopher Dawson

open access: yes, 2009
Christopher Dawson (1889-1970) was one of his generation's most important historians and religious thinkers, and was a significant influence on many contemporaries including T.S. Eliot, C.S. Lewis, and Russell Kirk. This dissertation is a study of his
Sproviero, Glen A.
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Formal schooling and self construction: a historical-cultural narrative approach [PDF]

open access: yes, 2015
Mata Benítez, Manuel de La   +4 more
core  

Creation of Educational 3D visualisations of a cultural world Heritage Site: Saltaire Case Study

open access: yes
A world heritage site consists of cultural, archaeological and historic site which includes monuments, buildings, lake, forest and geographical structures as well as cities which have significance importance.
Pande, Preeti
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Sustainable urban planning patterns and techniques in historical contextsCase study (Bolaghi neighborhood of Qazvin) [PDF]

open access: yesتحقیقات کاربردی علوم جغرافیایی
Historical contexts have rich cultural and cultural resources and are not very important not only because of the existence of valuable historical buildings and spaces, but also because they are real narratives of the life and activities of human beings ...
Amir Alimmohamadi   +3 more
doaj  

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