Results 141 to 150 of about 140,262 (309)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Cultural-Historical Theory in a Dialectical Optic [PDF]

open access: yes, 2019
This is review of the book: M. Dafermos. Rethinking Cultural-Historical Theory. A Dialectical Perspective to Vygotsky. (Springer: Singapore, 2018. IX, 309 P. ISBN 978‒981‒13‒0190‒2. Doi: 10.1007/978‒981‒13‒0191‒9).
Bazhanov, Valentin A.
core  

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Historical consciousness and strategies of detraumatization of historical culture in the modern world

open access: yesStudia Humanitatis, 2019
The article presents the socio-philosophical analysis of detraumatization and its main strategies in modern historical culture. Detraumatization was interpreted as the cultural practice of reformatting the semantic structure of relations between the past
Linchenko Andrei Aleksandrovich
doaj  

2º Webinar: “Cómic en lenguas indígenas: Kaqchikel y Quechua”. COST action CA19119 - ICOnMICs

open access: yes
Focusing on comics in indigenous languages, the event chaired by Prof. dr. Diana Castilleja (Vrije Universiteit Brussel, UCLouvain Saint-Louis Bruxelles), brings together authors, specialists and publishers in kaqchikel and quechua as part of the lines ...
Castilleja, Diana   +1 more
core  

The life cycle approach as an innovative methodology for the recovery and restoration of cultural heritage

open access: yes, 2014
Purpose – In this paper, of exploratory character, the purpose of this paper is to propose the analysis of the life cycle for assessing the environmental, economic, and social impact in the activity of recovery, restoration, and valorization of ...
Pini M.   +10 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Historical Replication Preserves Cultural Heritage [PDF]

open access: yes, 2019
We propose a radically new approach to deal with major negative effects resulting from overtourism. The major attractions of heavily visited historical sites are to be identically replicated in a new location emphasizing a vivid historical experience ...
Briviba, Andre, Frey, Bruno S.
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

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