Threonine 348 regulates the subcellular localization of PTEN
FEBS Open Bio, EarlyView.Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley +1 more source
Sustainable urban planning patterns and techniques in historical contextsCase study (Bolaghi neighborhood of Qazvin) [PDF]
تحقیقات کاربردی علوم جغرافیاییHistorical contexts have rich cultural and cultural resources and are not very important not only because of the existence of valuable historical buildings and spaces, but also because they are real narratives of the life and activities of human beings ...
Amir Alimmohamadi +3 more
doaj
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
FEBS Open Bio, EarlyView.Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Learning to write from the historical - cultural approach
Revista MENDIVE, 2010 The conceptions of Lev Semionovich Vigotski and his followers are paradigmatic in different fields of knowledge. This article takes on special significance in the learning of writing in mother and foreign languages. Because of the influence of the historical-cultural tendency in the teaching-learning process of foreign languages nowadays, the objective
openaire +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Past, Present and Future: A Historical Analysis and Reflection of 100 Years of Nursing Leadership. [PDF]
Nurs InqBolton S +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
A space syntax approach to sustainable design for public spaces in historic cities. [PDF]
PLoS OneZhu Y, Huang L, Xie C, Chen W.
europepmc +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
The weight of the elephant(s): rethinking the tyranny of tradition in modern paramedic education. [PDF]
Br Paramed JBrogan J.
europepmc +1 more source