Results 131 to 140 of about 140,262 (309)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Response to Commentary “Cultural-Historical Neuropsychology and ADHD” by Prof. Tatiana V. Akhutina

open access: yesКультурно-историческая психология
The present short review contains the authors response to Commentary “Cultural-Historical Neuropsychology and ADHD” by Prof. Tatiana V.
A. Koutsoklenis   +2 more
doaj   +1 more source

CULTURE UNDER A HISTORICAL-CULTURAL PERSPECTIVE: FIRST APPROACHES

open access: yesTravessias, 2008
 This paper derives from a study developed in a Masters Degree lato sensu course focusing the Historical-Cultural Theory, which was offered by the State University of Maringá-UEM. It is an investigation, in first approach, regarding the meaning of ‘culture’, according to what is postulated by the Historical-Cultural Theory.
openaire   +2 more sources

Māori Cultural Identity and Education

open access: yes, 2013
Underachievement of Māori students in mainstream schools has been a major topic of discussion by politicians and educational researchers in recent years.
Hawaikirangi-Pere, Charmaine
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

UN INTENTO DE SISTEMATIZACIÓN DE LOS PLANTEAMIENTOS ESENCIALES DEL ENFOQUE HISTÓRICO CULTURAL EN SUS INICIOS

open access: yesPsicologia, 2005
This article intends to present trial systematization and the general concepts of Historical Cultural Approach content¿s, considering its beginning. The article presents several reflections about the reasons that allow considering the historical cultural
Guillermo Arias Beatón
doaj  

Historical Perception of Architecture and Cultural History Approach

open access: yesArt and Design Review, 2018
The experts and specialists in the field of architecture have had different viewpoints and approaches in defining the concepts of “history” and “the history of architecture”, all through the compiled history of architecture. Analysis of these viewpoints that are sometimes in contrast and sometimes similar to each other brings forward some questions in ...
openaire   +2 more sources

What does captain cook have to tell us about culture? Contributions for a structural and historical approach to culture and organizations

open access: yes, 2009
Current approaches to culture and organizations fail to define culture dynamics as inextricably wrapped up with the dynamics of cultural resources.
Vasconcelos, Flávio Carvalho de   +1 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

An Attempt to the Systematization of Essentials Contents of Historical Cultural Approach

open access: yesPsicologia, 2005
This article intends to present trial systematization and the general concepts of Historical Cultural Approach content’s, considering its beginning. The article presents several reflections about the reasons that allow considering the historical cultural
Guillermo Arias Beatón
doaj  

Home - About - Disclaimer - Privacy