Results 121 to 130 of about 184,283 (297)

CULTURE UNDER A HISTORICAL-CULTURAL PERSPECTIVE: FIRST APPROACHES

Travessias, 2008
 This paper derives from a study developed in a Masters Degree lato sensu course focusing the Historical-Cultural Theory, which was offered by the State University of Maringá-UEM. It is an investigation, in first approach, regarding the meaning of ‘culture’, according to what is postulated by the Historical-Cultural Theory.
openaire   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

UN INTENTO DE SISTEMATIZACIÓN DE LOS PLANTEAMIENTOS ESENCIALES DEL ENFOQUE HISTÓRICO CULTURAL EN SUS INICIOS

Psicologia, 2005
This article intends to present trial systematization and the general concepts of Historical Cultural Approach content¿s, considering its beginning. The article presents several reflections about the reasons that allow considering the historical cultural
Guillermo Arias Beatón
doaj  

Integrating agents and virtual institutions for sharing cultural heritage on the Web

, 2009
This work outlines the research activities carried out by our groups in the direction of the implementation of a tool for sharing natural and cultural heritage on the web. The tool will serve as a support to teachers and people involved in scientific and
Ancona, Massimo, Mascardi, Viviana, Simoff, Simeon J., Traverso, Antonella, Papaleo, Laura, Quercini, Gianluca, Cohen, Alex S., Bogdanovych, Anton   +7 more
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Historical consciousness and strategies of detraumatization of historical culture in the modern world

Studia Humanitatis, 2019
The article presents the socio-philosophical analysis of detraumatization and its main strategies in modern historical culture. Detraumatization was interpreted as the cultural practice of reformatting the semantic structure of relations between the past
Linchenko Andrei Aleksandrovich
doaj  

Conceiving Concepts and Conceptions: A Cultural-Historical Approach

, 2011
A science that does not critically interrogate its theoretical concepts literally does not know what it is doing. The attempt to clarify a widely used concept in psychological research-the concept of concept-therefore constitutes an important effort in ...
Wolff-Michael Roth, Roth, Wolff-Michael
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source