Results 101 to 110 of about 198,327 (301)

Marxism, Cultural Studies, and the “Principle Of Historical Specification”: On The Form of Historical Time in Conjunctural Analysis

Lateral, 2018
Karl Korsch identifies in Marx’s work what he calls “the principle of historical specification,” the way in which “Marx comprehends all things social in terms of a definite historical epoch.” This work is concerned with this idea and its instantiation in
Douglas Spielman
doaj   +1 more source

Narrative as Cultural Mediator in Personality Development: Looking through the Lens of Cultural-Historical Psychology

Культурно-историческая психология, 2016
The article considers the features of the narrative approach as a new methodology for the study of personality and its development mechanisms. The article discusses the basic settings of social constructionism, in which most of the narrative research are
Turusheva Y.B.,
doaj   +1 more source

ADHD Diagnosis from the Perspective of Cultural-Historical Neuropsychology

Культурно-историческая психология
The diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD) has been a subject of enduring debates, with numerous discussions challenging its validity and questioning the evidence that supports its existence.
A. Koutsoklenis, Y. Solovieva, L. Quintanar   +2 more
doaj   +1 more source

HUMAN DEVELOPMENT, COGNITION AND SCHOOL EDUCATION: REFLECTIONS BELOW THE HISTORICAL-CULTURAL APPROACH

Reflexão & Ação, 2016
This text is fruit of studies, reflections and dialogues developed with graduate and post-graduate students inteaching and research coordinated by me, allocated in the research group: Human Development, Culture and Education, in rows : Language, Learning
Solange Maria Alves
doaj   +1 more source

The life cycle approach as an innovative methodology for the recovery and restoration of cultural heritage

, 2014
Purpose – In this paper, of exploratory character, the purpose of this paper is to propose the analysis of the life cycle for assessing the environmental, economic, and social impact in the activity of recovery, restoration, and valorization of ...
Pini M., García, José Francisco, Ferrari A. M., Fernández del, Hoyo Alfonso Pedro, PINI, MARTINA, Settembre, Blundo Davide, SETTEMBRE BLUNDO, DAVIDE, Fernández del Hoyo A. P., FERRARI, Anna Maria, Riccardi, Maria Pia, García J. F.   +10 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Do We Care about Built Cultural Heritage? The Empirical Evidence Based on the Veneto House Market [PDF]

Italian historical buildings require urgent and costly maintenance and restoration works, but neither the local, nor the national public administrators can afford these expenditures. Nevertheless the built cultural heritage represent a unique resource of
Lucia Rotaris, Margaretha Breil, Valentina Zanatta, Paolo Rosato   +3 more
core