Results 81 to 90 of about 198,327 (301)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Culture-led Urban Regeneration- An Example from Zong-Ye Historical District in Tainan [PDF]
The impacts of globalization force Asian countries face the problems of transformation, this paper aim to discuss how to keep the local identification and cultural characteristic under the wave of globalization.
Chengche Chen, Hsienhsin Cheng
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Possibilities of the Cultural-Historical Approach to Gender Issues [PDF]
Background. The relevance of gender issues is associated with discussions outside the scientific field, while in the science itself, the popularity of gender studies is increasing every year. Objectives.
Sergey K. Kumchenko +1 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Michael Cole as the Mediator and Integrator of Cultural-Historical Psychology
Культурно-историческая психология, 2018 The article describes the ideas and tuning points of M. Cole's career — the famous American psychologist, his theoretical, methodological and empirical contribution to modern psychology. It is composed of three sections.
Meshcheryakov B.G.,, Ponomarev I.V.,
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Evolution of Cultural Traits Occurs at Similar Relative Rates in Different World Regions [PDF]
, 2014 A fundamental issue in understanding human diversity is whether or not there are regular patterns and processes involved in cultural change. Theoretical and mathematical models of cultural evolution have been developed and are increasingly being used and
Currie, TE, Mace, R
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Cultural-Historical Theory in a Dialectical Optic [PDF]
, 2019 This is review of the book: M. Dafermos. Rethinking Cultural-Historical Theory. A Dialectical Perspective to Vygotsky. (Springer: Singapore, 2018. IX, 309 P. ISBN 978‒981‒13‒0190‒2. Doi: 10.1007/978‒981‒13‒0191‒9).
Bazhanov, Valentin A.
core +1 more source
, 2020 An integrate approach, aimed at allowing the access to a large dataset, concerning Cultural Heritage, is proposed. The research, developed within Databenc-SNECS (High-Tech District for Cultural Heritage – Social Network of Historic Center Entities ...
Morra V. +15 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source