Results 71 to 80 of about 198,327 (301)

A Cultural-Historical Approach to Learning in Classrooms

Outlines. Critical Practice Studies, 2004
The basic conception of this paper is to conceptualise learning as a change in relation between a person and the world through change in his/her capacity for tool use and interpretation of artefacts. Further this relation has to be defined within a context (state, societal field, institutional practice and person’s activity).
openaire   +3 more sources

Time frames. Negotiating Cultural History

, 2015
Time Frames brings together a group of cultural historians studying several different periods and locations in the history of Western culture, to discuss the temporal structures which historical studies live by.
Tuohela, Kirsi (toim.), Korhonen, Anu
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Digital Preservation:A New Approach to Protecting Historical and Cultural Towns and Villages

Contemporary Social Sciences, 2018
Digital technology has penetrated all aspects of modern life and is pushing society forward by profoundly changing the way people live and think.It can not only eternalize cultural heritage,but also allow relevant knowledge to be spread more quickly and ...
Liu Peilin
doaj   +1 more source

Cultural-historical perspective in Spain and Portugal: developing theoretical and methodological approaches [PDF]

, 2020
Cultural-historical research has had a relevant presence in Spain and, to a lesser extent, in Portugal, since the 1970s. A review of the state of the art of the cultural-historical approach in these two countries allows us to identify four general lines ...
Mata Benítez, Manuel de La, Rebollo Catalán, María Ángeles, Santamaría Santigosa, Andrés, Aires, María Luisa Lebres, Cubero Pérez, Mercedes, García Pérez, Rafael   +5 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

The results of the study of mass ceramics from the excavations at the medieval fortifi ed settlement of Ken-Bulun in 2022 (Chui Valley, Kyrgyzstan)

Поволжская археология
The article presents the results of a thorough study of ceramic finds from the Ken-Bulun settlement of the Chuy region of Kyrgyzstan, obtained during the 2022 field season.
Kuklina Anna A. , Kolchenko Valerii A.
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Results of the Technical and Technological Analysis of the Wares from the Novoilyinskiy Culture Sites of the Lower Kama Region

Археология евразийских степей
For the first time, a technical and technological analysis of the ceramics of the Novoilyinskiy culture was carried out within the historical and cultural approach proposed by A.A. Bobrinsky.
Olga V. Andreeva
doaj   +1 more source

Examining teacher education through cultural-historical activity theory [PDF]

Cultural-historical activity theory (CHAT) is an approach that can be used to analyse human interactions and relationships within particular social contexts.
Wilson, Viv
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