Results 61 to 70 of about 198,327 (301)

Motives in Children's Development: Cultural-Historical Approaches

open access: yes, 2012
the book has the term cultural-historical approaches in its title to indicate its origin in the cultural-historical approach of lev vygotsky.vi, 230 hlm.; 25 ...
Marilyn Fleer   +2 more
core   +1 more source

Chronology and Dynamics of Ancient Pottery Traditions’ Dissemination in Steppes of the Lower Volga Region

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2018
The territory of the Lower Volga plays an important role in the study of the Neolithic of Eastern Europe. The leading indicator of this epoch is pottery. Determining the chronology of pottery making is one of the most complex issues.
Aleksandr A. Vybornov   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

A systematic review on spatial-based valuation approach for built cultural heritage [PDF]

open access: yes, 2019
This paper reviews previous research that has been carried out to assess the value of built cultural heritage based on spatial-based valuation approach. Built cultural heritage is classified as a special property and can be categorised under thin market ...
Ismail, Suriatini   +4 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Models of Relationship between Training and Psyche development in Cultural-historical and Activity Approaches

open access: yesПсихологическая наука и образование (2007. Online), 2016
The possibility of referring of the psychological theories studying interrelation of training and mental development processes to this or that stage of scientific knowledge formation on the basis of studied objects types and corresponded determination ...
Pogozhina I.N.,
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

An Attempt to the Systematization of Essentials Contents of Historical Cultural Approach

open access: yesPsicologia, 2005
This article intends to present trial systematization and the general concepts of Historical Cultural Approach content’s, considering its beginning. The article presents several reflections about the reasons that allow considering the historical cultural
Guillermo Arias Beatón
doaj  

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