Results 91 to 100 of about 198,327 (301)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Vygotsky in applied neuropsychology
Psychology in Russia: State of Art, 2016 The aims of this paper are: 1) to show the role of clinical experience for the theoretical contributions of L.S. Vygotsky, and 2) to analyze the development of these theories in contemporary applied neuropsychology.
Glozman J. M.
doaj +1 more source
Norwegian cultural policy: a civilising mission? [PDF]
This dissertation aims to explore the extent to which what has been termed „the civilising mission‟ has been a central rationale behind Norwegian cultural policy.
Bjørnsen, Egil
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Cultural Dimension of the Communist Party in Manzanillo (1925-1935)
Santiago, 2015 The present research work, a partial result of a scientific project, allows an approach to the activity of Manzanillo communists during the stage from 1925 to 1935.
MSc. Aida Mercedes Sera-Fernández
doaj
From representations to representing: On social representations and discursive-rhetorical psychology [PDF]
, 2015 This chapter focusses on active processes of representing, and does so by exploring the links between social representations theory, discourse analysis and rhetorical psychology.
Stephen Gibson +2 more
core +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
The Main Approaches to Historical and Cultural Analysis of the Films [PDF]
nauka.me, 2017 The article deals with the XX century — a century of active development, the visual technology diffusion, that have shaped a new way of thinking. Nowadays we can note the special role of «visuality» in everyday life, which has become almost ubiquitous: movies, advertising, photo signboard, television.
openaire +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source